Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

G. Smith; S. H. Ibbotson; M. M. Comrie; R. S. Dawe; A. Bryden; J. Ferguson; C. R. Wolf

doi:10.1111/j.1365-2133.2006.07317.x

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

G. Smith, S. H. Ibbotson, M. M. Comrie, R. S. Dawe, A. Bryden, J. Ferguson, C. R. Wolf

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP) genes is an important determinant of treatment response. There is increasing evidence that many DMEs and CP genes are also expressed in human skin. Responses to topical drugs used to treat common skin diseases, such as psoriasis, are unpredictable and may potentially be rationalized, at least in part, by interindividual differences in cutaneous DME and CP gene expression.

Original language	English
Pages (from-to)	275-81
Number of pages	7
Journal	British Journal of Dermatology
Volume	155
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2133.2006.07317.x
Publication status	Published - 2006

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10.1111/j.1365-2133.2006.07317.x

45 Citations
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Corrigendum: Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo (British Journal of Dermatology (2006) 155 (275-281))
Smith, G., Ibbotsom, S. H., Comrie, M. M., Dawe, R. S., Bryden, A., Ferguson, J. & Wolf, C. R., Oct 2006, In: British Journal of Dermatology. 155, 4, p. 841–865 1 p.
Research output: Contribution to journal › Comment/debate › peer-review

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title = "Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo",

abstract = "Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP) genes is an important determinant of treatment response. There is increasing evidence that many DMEs and CP genes are also expressed in human skin. Responses to topical drugs used to treat common skin diseases, such as psoriasis, are unpredictable and may potentially be rationalized, at least in part, by interindividual differences in cutaneous DME and CP gene expression.",

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AU - Dawe, R. S.

AU - Bryden, A.

AU - Ferguson, J.

AU - Wolf, C. R.

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AB - Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP) genes is an important determinant of treatment response. There is increasing evidence that many DMEs and CP genes are also expressed in human skin. Responses to topical drugs used to treat common skin diseases, such as psoriasis, are unpredictable and may potentially be rationalized, at least in part, by interindividual differences in cutaneous DME and CP gene expression.

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Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

Abstract

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Research output

Corrigendum: Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo (British Journal of Dermatology (2006) 155 (275-281))

Cite this