Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

G. Smith, S. H. Ibbotson, M. M. Comrie, R. S. Dawe, A. Bryden, J. Ferguson, C. R. Wolf

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)

    Abstract

    Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP) genes is an important determinant of treatment response. There is increasing evidence that many DMEs and CP genes are also expressed in human skin. Responses to topical drugs used to treat common skin diseases, such as psoriasis, are unpredictable and may potentially be rationalized, at least in part, by interindividual differences in cutaneous DME and CP gene expression.
    Original languageEnglish
    Pages (from-to)275-81
    Number of pages7
    JournalBritish Journal of Dermatology
    Volume155
    Issue number2
    DOIs
    Publication statusPublished - 2006

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