Regulation of gene expression by hypoxia

Niall Steven Kenneth, Sonia Rocha

    Research output: Contribution to journalReview articlepeer-review

    169 Citations (Scopus)

    Abstract

    Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF regulation have greatly enhanced our knowledge of the molecular aspects of the hypoxic response. However, in addition to HIF, other transcription factors and cellular pathways are activated by exposure to reduced oxygen. In the present review, we summarize the current knowledge of how additional hypoxia-responsive transcription factors integrate with HIF and how other cellular pathways Such LIS chromatin remodelling, translation regulation and microRNA induction, contribute to the co-ordinated cellular response observed following hypoxic stress.

    Original languageEnglish
    Pages (from-to)19-29
    Number of pages11
    JournalBiochemical Journal
    Volume414
    Issue number1
    DOIs
    Publication statusPublished - 15 Aug 2008

    Keywords

    • chromatin
    • hypoxia
    • hypoxia-inducible factor (HIF)
    • microRNA (miRNA)
    • transcription
    • translation
    • NF-KAPPA-B
    • INDUCIBLE FACTOR-I
    • MESSENGER-RNA TRANSLATION
    • MYC TRANSCRIPTIONAL ACTIVITY
    • INTEGRATED STRESS-RESPONSE
    • ENDOTHELIAL GROWTH-FACTOR
    • PROMOTES TUMOR-GROWTH
    • CELL-CYCLE ARREST
    • C-MYC
    • P53-DEPENDENT TRANSACTIVATION

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