TY - JOUR
T1 - Regulation of innate immunity by Nrf2
AU - van der Horst, D.
AU - Carter-Timofte, M. E.
AU - van Grevenynghe, J.
AU - Laguette, N.
AU - Dinkova-Kostova, Albena T.
AU - Olagnier, David
N1 - Funding Information:
This research was funded by the Lundbeck Foundation ( R335-2019-2138 ), the Kræftens Bekæmpelse ( R279-A16218 ), the Independent Research Fund Denmark ( 1026-00003B ), the Brødrene Hartman Fonden , the Hørslev Fonden , the Einar Willumsens mindelegat, the Eva og Henry Frænkels mindefond, the Beckett Fonden, the Lily Benthine Lunds fonden, and the Sofus Carl Emil Friis Legat to D.O. NL is supported by the “ Agence Nationale de Recherche sur le SIDA et les Hépatites virales (ANRS: ECTZ117448 )”, the “fondation ARC pour la recherche sur le cancer”, the “ Région Languedoc Roussillon ”, the “ Centre Nationale pour la Recherche Scientifique ” (CNRS), and the French government within the Plan d′investissements France 2030. DvdH salary was supported in part by the Biomedicine department at Aarhus University . DvdH was also supported by the Dansk Kræftforksning fond . M.E.C-T salary was supported by a Kræftens Bekæmpelse postdoctoral fellowship (R306-A18092).
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/10
Y1 - 2022/10
N2 - The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly investigated as a regulator of redox homeostasis. However, research over the past years has implicated Nrf2 as an important regulator of innate immunity. Here, we discuss the role of Nrf2 in the innate immune response, highlighting the interaction between Nrf2 and major components of the innate immune system. Indeed, Nrf2 has been shown to widely control the immune response by interacting directly or indirectly with important innate immune components, including the toll-like receptors-Nuclear factor kappa B (NF-kB) pathway, inflammasome signaling, and the type-I interferon response. This indicates an essential role for Nrf2 in diseases related to microbial infections, inflammation, and cancer. Yet, further studies are required to determine the exact mechanism underpinning the interactions between Nrf2 and innate immune players in order to allow a better understanding of these diseases and leverage new therapeutic strategies.
AB - The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly investigated as a regulator of redox homeostasis. However, research over the past years has implicated Nrf2 as an important regulator of innate immunity. Here, we discuss the role of Nrf2 in the innate immune response, highlighting the interaction between Nrf2 and major components of the innate immune system. Indeed, Nrf2 has been shown to widely control the immune response by interacting directly or indirectly with important innate immune components, including the toll-like receptors-Nuclear factor kappa B (NF-kB) pathway, inflammasome signaling, and the type-I interferon response. This indicates an essential role for Nrf2 in diseases related to microbial infections, inflammation, and cancer. Yet, further studies are required to determine the exact mechanism underpinning the interactions between Nrf2 and innate immune players in order to allow a better understanding of these diseases and leverage new therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85138790279&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2022.102247
DO - 10.1016/j.coi.2022.102247
M3 - Review article
C2 - 36174411
SN - 0952-7915
VL - 78
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102247
ER -
