Regulation of mRNA cap methylation

    Research output: Contribution to journalReview articlepeer-review

    80 Citations (Scopus)

    Abstract

    The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.

    Original languageEnglish
    Pages (from-to)295-302
    Number of pages8
    JournalBiochemical Journal
    Volume425
    DOIs
    Publication statusPublished - 15 Jan 2010

    Keywords

    • gene regulation
    • mRNA cap methylation
    • translation
    • transcription
    • S-ADENOSYLHOMOCYSTEINE HYDROLASE
    • CAPPING ENZYME
    • POLYMERASE-II
    • FISSION YEAST
    • SACCHAROMYCES-CEREVISIAE
    • TRANSCRIPTION ELONGATION
    • CONDITIONAL MUTANTS
    • BINDING COMPLEX
    • IN-VIVO
    • P-TEFB

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