Regulation of mRNA cap methylation

Victoria H. Cowling

doi:10.1042/BJ20091352

Regulation of mRNA cap methylation

Victoria H. Cowling

Research output: Contribution to journal › Review article › peer-review

169 Citations (Scopus)

Abstract

The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.

Original language	English
Pages (from-to)	295-302
Number of pages	8
Journal	Biochemical Journal
Volume	425
DOIs	https://doi.org/10.1042/BJ20091352
Publication status	Published - 15 Jan 2010

Keywords

gene regulation
mRNA cap methylation
translation
transcription
S-ADENOSYLHOMOCYSTEINE HYDROLASE
CAPPING ENZYME
POLYMERASE-II
FISSION YEAST
SACCHAROMYCES-CEREVISIAE
TRANSCRIPTION ELONGATION
CONDITIONAL MUTANTS
BINDING COMPLEX
IN-VIVO
P-TEFB

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10.1042/BJ20091352

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)
Cowling, V. (Investigator)
3/12/07 → 2/01/14
Project: Research

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title = "Regulation of mRNA cap methylation",

abstract = "The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.",

keywords = "gene regulation, mRNA cap methylation, translation, transcription, S-ADENOSYLHOMOCYSTEINE HYDROLASE, CAPPING ENZYME, POLYMERASE-II, FISSION YEAST, SACCHAROMYCES-CEREVISIAE, TRANSCRIPTION ELONGATION, CONDITIONAL MUTANTS, BINDING COMPLEX, IN-VIVO, P-TEFB",

author = "Cowling, {Victoria H.}",

year = "2010",

month = jan,

day = "15",

doi = "10.1042/BJ20091352",

language = "English",

volume = "425",

pages = "295--302",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "Portland Press",

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TY - JOUR

T1 - Regulation of mRNA cap methylation

AU - Cowling, Victoria H.

PY - 2010/1/15

Y1 - 2010/1/15

N2 - The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.

AB - The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.

KW - gene regulation

KW - mRNA cap methylation

KW - translation

KW - transcription

KW - S-ADENOSYLHOMOCYSTEINE HYDROLASE

KW - CAPPING ENZYME

KW - POLYMERASE-II

KW - FISSION YEAST

KW - SACCHAROMYCES-CEREVISIAE

KW - TRANSCRIPTION ELONGATION

KW - CONDITIONAL MUTANTS

KW - BINDING COMPLEX

KW - IN-VIVO

KW - P-TEFB

U2 - 10.1042/BJ20091352

DO - 10.1042/BJ20091352

M3 - Review article

C2 - 20025612

SN - 0264-6021

VL - 425

SP - 295

EP - 302

JO - Biochemical Journal

JF - Biochemical Journal

ER -

Regulation of mRNA cap methylation

Abstract

Keywords

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Projects

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)

Cite this