Regulation of mRNA capping in the cell cycle

Michael Aregger, Victoria H. Cowling (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    14 Citations (Scopus)
    200 Downloads (Pure)

    Abstract

    The mRNA cap structure, which is added to nascent RNA pol II transcripts, recruits the protein complexes required for pre-mRNA transcript processing, mRNA export and translation initiation. The enzymes which catalyse mRNA cap synthesis are regulated by cellular signaling pathways which impact on their expression, localisation and activity. Here we discuss the recent observation that the mRNA cap methyltransferase, RNMT, is phosphorylated on Thr-77 by CDK1-cyclin B1, which regulates its activity and the proteins with which it interacts. RNMT Thr-77 phosphorylation provides a burst of mRNA cap methyltransferase activity during early G1 phase at a time when transcription is reactivated following completion of the cell cycle. This co-ordination of transcription and mRNA capping makes an important contribution to gene expression in the cell; preventing RNMT Thr-77 phosphorylation inhibits cell proliferation. Here we discuss these findings and how mRNA cap synthesis may be regulated in other scenarios.

    Original languageEnglish
    Pages (from-to)11-14
    Number of pages4
    JournalRNA Biology
    Volume14
    Issue number1
    Early online date28 Oct 2016
    DOIs
    Publication statusPublished - 2 Jan 2017

    Keywords

    • transcription
    • translation
    • gene expression
    • mRNA
    • mRNA cap
    • RNMT
    • phosphorylation
    • cell cycle

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