Regulation of ptdins-3-kinase and the guanine nucleotide binding proteins p21ras during signal transduction by the t cell antigen receptor and the interleukin-2 receptor

D. A. Cantrell, M. Izquierdo, K. Reif, M. Woodrow

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The T cell antigen receptor (TCR) and the interleukin-2 receptor (IL-2R) are important receptors in haematopoiesis since they control the activation and growth of T lymphocytes, respectively. The term T cell activation refers to the events that occur as T cells progress from the G0 to the G1 phase of the cell cycle and is characterised by the production of a wide range of cytokines and other immunomodulators crucial for the growth and development of other haematopoietic cells. Activation also induces the T cells to express on their cell surface high affinity receptors for various cytokines which enable the T cell to respond to the different cytokines generated during an immune response. One well characterised event that occurs when mature T cells are activated is the production of the cytokine IL-2 and the acquisition by the T cell of high affinity IL-2 receptors. Interaction between IL-2 and its cellular receptor then direct T cell growth. One notable difference between TCR and IL-2R signal transduction is that the TCR regulates intracellular calcium and stimulates protein kinase C whereas the IL-2 receptor does not. The present review focuses on TCR and IL-2R regulation of two common intracellular signalling pathways: the regulation of a PtdIns-3-kinase and the activation of the guanine nucleotide binding proteins p21ras. The aim is to illustrate differences in the mechanisms that couple the TCR and IL-2R to these two signalling pathways and attempt to explain the apparent discrepancy of TCR and IL-2R regulation of shared signal transduction pathways even though these receptors mediate quite distinct biological responses.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalSeminars in Immunology
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 1993

Keywords

  • C-raf
  • Interleukin-2 receptor
  • MAP kinase
  • P21
  • PtdIns-3-kinase

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