Regulation of the activity and expression of ERK8 by DNA damage

Iva V. Klevernic; Niall M. B. Martin; Philip Cohen

doi:10.1016/j.febslet.2009.01.011

Regulation of the activity and expression of ERK8 by DNA damage

Iva V. Klevernic, Niall M. B. Martin, Philip Cohen

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Abstract

We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	680-684
Number of pages	5
Journal	FEBS Letters
Volume	583
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2009.01.011
Publication status	Published - 18 Feb 2009

Keywords

ERK8
MAPK
DNA damage
MMS

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10.1016/j.febslet.2009.01.011

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title = "Regulation of the activity and expression of ERK8 by DNA damage",

abstract = "We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

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AU - Klevernic, Iva V.

AU - Martin, Niall M. B.

AU - Cohen, Philip

PY - 2009/2/18

Y1 - 2009/2/18

N2 - We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - ERK8

KW - MAPK

KW - DNA damage

KW - MMS

U2 - 10.1016/j.febslet.2009.01.011

DO - 10.1016/j.febslet.2009.01.011

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SP - 680

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JO - FEBS Letters

JF - FEBS Letters

IS - 4

ER -

Regulation of the activity and expression of ERK8 by DNA damage

Abstract

Keywords

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