Regulation of the activity and expression of ERK8 by DNA damage

Iva V. Klevernic, Niall M. B. Martin, Philip Cohen

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    Abstract

    We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)680-684
    Number of pages5
    JournalFEBS Letters
    Volume583
    Issue number4
    DOIs
    Publication statusPublished - 18 Feb 2009

    Keywords

    • ERK8
    • MAPK
    • DNA damage
    • MMS

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