Projects per year
Abstract
The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic a-subunit and regulatory ß- and FXYD subunits. All three subunits may become palmitoylated, although the functional outcome of these palmitoylation events is incompletely characterized to date. Interestingly, both ß- and FXYD subunits may be palmitoylated or glutathionylated at the same cysteine residues. These competing chemically distinct post-translational modifications may mediate functionally different effects on the cardiac pump. In the present article, we review the cellular events that control the balance between these modifications, and discuss the likely functional effects of pump subunit palmitoylation.
Original language | English |
---|---|
Pages (from-to) | 95-100 |
Number of pages | 6 |
Journal | Biochemical Society Transactions |
Volume | 41 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2013 |
Fingerprint
Dive into the research topics of 'Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Regulation of the Cardiac Sodium Pump by Palmitoylation
Ashford, M. (Investigator) & Fuller, W. (Investigator)
15/11/12 → 14/11/13
Project: Research