Regulation of the cardiac sodium pump

W. Fuller, L.B. Tulloch, J. Howie, K.J. Wypijewski, M.J. Shattock, S.C. Calaghan

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    Abstract

    In cardiac muscle, the sarcolemmal sodium/potassium ATPase is the principal quantitative means of active transport at the myocyte cell surface, and its activity is essential for maintaining the trans-sarcolemmal sodium gradient that drives ion exchange and transport processes that are critical for cardiac function. The 72-residue phosphoprotein phospholemman regulates the sodium pump in the heart: unphosphorylated phospholemman inhibits the pump, and phospholemman phosphorylation increases pump activity. Phospholemman is subject to a remarkable plethora of post-translational modifications for such a small protein: the combination of three phosphorylation sites, two palmitoylation sites, and one glutathionylation site means that phospholemman integrates multiple signaling events to control the cardiac sodium pump. Since misregulation of cytosolic sodium contributes to contractile and metabolic dysfunction during cardiac failure, a complete understanding of the mechanisms that control the cardiac sodium pump is vital. This review explores our current understanding of these mechanisms.
    Original languageEnglish
    Pages (from-to)1357-1380
    Number of pages24
    JournalCellular and Molecular Life Sciences
    Volume70
    Issue number8
    DOIs
    Publication statusPublished - Apr 2012

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    Fuller, W., Tulloch, L. B., Howie, J., Wypijewski, K. J., Shattock, M. J., & Calaghan, S. C. (2012). Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), 1357-1380. https://doi.org/10.1007/s00018-012-1134-y