Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene

Sergio Moreno, Karim Labib, Jaime Correa, Paul Nurse

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    Abstract

    We have identified the rum1(+) gene as a new regulator of the G(1)-phase of the fission yeast cell cycle. rum1(+) determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1(+) are unable to arrest in pre-Start G(1) in response to nitrogen starvation and are subsequently sterile. In addition, rum1(+) prevents entry into mitosis from pre-Start G(1), as shown by the fact that cdc10 mutants in the absence of rum1(+) undergo lethal mitosis without entering S-phase.

    Original languageEnglish
    Pages (from-to)63-68
    Number of pages6
    JournalJournal of Cell Science
    DOIs
    Publication statusPublished - 1994

    Keywords

    • FIBROBLASTS
    • INHIBITOR
    • S-PHASE
    • SCHIZOSACCHAROMYCES-POMBE
    • RUM1(+)
    • DIVISION
    • START
    • COMPLEX
    • SCHIZOSACCHAROMYCES POMBE
    • DNA-REPLICATION
    • CELL CYCLE
    • IDENTIFICATION
    • SACCHAROMYCES-CEREVISIAE
    • MITOSIS

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