Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene

TY - JOUR

T1 - Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene

AU - Moreno, Sergio

AU - Labib, Karim

AU - Correa, Jaime

AU - Nurse, Paul

PY - 1994

Y1 - 1994

N2 - We have identified the rum1(+) gene as a new regulator of the G(1)-phase of the fission yeast cell cycle. rum1(+) determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1(+) are unable to arrest in pre-Start G(1) in response to nitrogen starvation and are subsequently sterile. In addition, rum1(+) prevents entry into mitosis from pre-Start G(1), as shown by the fact that cdc10 mutants in the absence of rum1(+) undergo lethal mitosis without entering S-phase.

AB - We have identified the rum1(+) gene as a new regulator of the G(1)-phase of the fission yeast cell cycle. rum1(+) determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1(+) are unable to arrest in pre-Start G(1) in response to nitrogen starvation and are subsequently sterile. In addition, rum1(+) prevents entry into mitosis from pre-Start G(1), as shown by the fact that cdc10 mutants in the absence of rum1(+) undergo lethal mitosis without entering S-phase.

KW - FIBROBLASTS

KW - INHIBITOR

KW - S-PHASE

KW - SCHIZOSACCHAROMYCES-POMBE

KW - RUM1(+)

KW - DIVISION

KW - START

KW - COMPLEX

KW - SCHIZOSACCHAROMYCES POMBE

KW - DNA-REPLICATION

KW - CELL CYCLE

KW - IDENTIFICATION

KW - SACCHAROMYCES-CEREVISIAE

KW - MITOSIS

U2 - 10.1242/jcs.1994.Supplement_18.9

DO - 10.1242/jcs.1994.Supplement_18.9

M3 - Article

SN - 0021-9533

SP - 63

EP - 68

JO - Journal of Cell Science

JF - Journal of Cell Science

ER -