Regulation of the RelA (p65) transactivation domain

John M. O'Shea, Neil D. Perkins

    Research output: Contribution to journalArticlepeer-review

    60 Citations (Scopus)


    The RelA (p65) NF-kappaB (nuclear factor kappaB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.
    Original languageEnglish
    Pages (from-to)603-8
    Number of pages6
    JournalBiochemical Society Transactions
    Issue numberPt 4
    Publication statusPublished - Aug 2008


    • Amino Acid Motifs
    • Animals
    • Gene Expression Regulation
    • Humans
    • Ligases
    • Protein Binding
    • Transcriptional Activation


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