Rejuvenating the immune system

Konstantinos Evangelou; Vassilis G. Gorgoulis

doi:10.1002/1878-0261.13802

Rejuvenating the immune system

Konstantinos Evangelou
, Vassilis G. Gorgoulis (Lead / Corresponding author)

MED Cancer Research

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

5 Downloads (Pure)

Abstract

Rejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al. reveals that the receptor activator of nuclear factor-κB (RANK)–RANK ligand (RANKL) axis is altered during age related thymic involution, compromising immune responses. Based on their findings, authors propose exogenous RANKL administration as a therapeutic strategy to reinvigorate thymic function and improve T-cell immunity during aging.

Original language	English
Pages (from-to)	584-587
Number of pages	4
Journal	Molecular Oncology
Volume	19
Issue number	3
Early online date	13 Jan 2025
DOIs	https://doi.org/10.1002/1878-0261.13802
Publication status	Published - 7 Mar 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aging
immune cells
RANKL
rejuvenation
thymus

ASJC Scopus subject areas

Molecular Medicine
Oncology
Genetics
Cancer Research

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10.1002/1878-0261.13802Licence: CC BY

Final Published VersionFinal published version, 600 KBLicence: CC BY

Cite this

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title = "Rejuvenating the immune system",

abstract = "Rejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al. reveals that the receptor activator of nuclear factor-κB (RANK)–RANK ligand (RANKL) axis is altered during age related thymic involution, compromising immune responses. Based on their findings, authors propose exogenous RANKL administration as a therapeutic strategy to reinvigorate thymic function and improve T-cell immunity during aging.",

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author = "Konstantinos Evangelou and Gorgoulis, \{Vassilis G.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Molecular Oncology published by John Wiley \& Sons Ltd on behalf of Federation of European Biochemical Societies.",

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AU - Evangelou, Konstantinos

AU - Gorgoulis, Vassilis G.

PY - 2025/3/7

Y1 - 2025/3/7

N2 - Rejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al. reveals that the receptor activator of nuclear factor-κB (RANK)–RANK ligand (RANKL) axis is altered during age related thymic involution, compromising immune responses. Based on their findings, authors propose exogenous RANKL administration as a therapeutic strategy to reinvigorate thymic function and improve T-cell immunity during aging.

AB - Rejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al. reveals that the receptor activator of nuclear factor-κB (RANK)–RANK ligand (RANKL) axis is altered during age related thymic involution, compromising immune responses. Based on their findings, authors propose exogenous RANKL administration as a therapeutic strategy to reinvigorate thymic function and improve T-cell immunity during aging.

KW - aging

KW - immune cells

KW - RANKL

KW - rejuvenation

KW - thymus

UR - https://www.scopus.com/pages/publications/85214702613

U2 - 10.1002/1878-0261.13802

DO - 10.1002/1878-0261.13802

M3 - Comment/debate

C2 - 39804992

AN - SCOPUS:85214702613

SN - 1574-7891

VL - 19

SP - 584

EP - 587

JO - Molecular Oncology

JF - Molecular Oncology

IS - 3

ER -

Rejuvenating the immune system

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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