Relation Between Body Composition, Systemic Inflammatory Response, and Clinical Outcomes in Patients Admitted to an Urban Teaching Hospital with COVID-19

TY - JOUR

T1 - Relation Between Body Composition, Systemic Inflammatory Response, and Clinical Outcomes in Patients Admitted to an Urban Teaching Hospital with COVID-19

AU - Mcgovern, Josh

AU - Dolan, Ross

AU - Richards, Conor

AU - Laird, Barry J.

AU - Mcmillan, Donald C.

AU - Maguire, Donogh

N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Background COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. Objectives The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19. Methods Patients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR, CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted. Results Sixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P < 0.05). Thirty-day mortality was associated with high VFA (P < 0.05) and low SMI (P < 0.05). Conclusions Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.

AB - Background COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. Objectives The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19. Methods Patients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR, CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted. Results Sixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P < 0.05). Thirty-day mortality was associated with high VFA (P < 0.05) and low SMI (P < 0.05). Conclusions Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.

KW - body composition

KW - COVID-19

KW - CT

KW - obesity

KW - sarcopenia

UR - https://www.scopus.com/pages/publications/85114069629

U2 - 10.1093/jn/nxab142

DO - 10.1093/jn/nxab142

M3 - Article

C2 - 34159388

AN - SCOPUS:85114069629

SN - 0022-3166

VL - 151

SP - 2236

EP - 2244

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 8

ER -