Relationship Between Maternal Arterial Wave Reflection, Microvascular Function and Fetal Growth in Normal Pregnancy

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    Abstract

    Objective: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.

    Methods: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.

    Results: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.

    Conclusion: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.

    Original languageEnglish
    Pages (from-to)608-614
    Number of pages7
    JournalMicrocirculation
    Volume17
    Issue number8
    DOIs
    Publication statusPublished - 2010

    Keywords

    • arterial stiffness
    • microcirculation
    • fetal growth
    • pregnancy
    • ENDOTHELIAL FUNCTION
    • PULSE-WAVE
    • AORTIC PRESSURE
    • MEDIATED VASODILATION
    • CARDIOVASCULAR EVENTS
    • CONSENSUS DOCUMENT
    • AUGMENTATION INDEX
    • PREECLAMPSIA
    • STIFFNESS
    • HUMANS

    Cite this

    @article{7834fa46257c404e95531f516773468e,
    title = "Relationship Between Maternal Arterial Wave Reflection, Microvascular Function and Fetal Growth in Normal Pregnancy",
    abstract = "Objective: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.Methods: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.Results: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.Conclusion: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.",
    keywords = "arterial stiffness, microcirculation, fetal growth, pregnancy, ENDOTHELIAL FUNCTION, PULSE-WAVE, AORTIC PRESSURE, MEDIATED VASODILATION, CARDIOVASCULAR EVENTS, CONSENSUS DOCUMENT, AUGMENTATION INDEX, PREECLAMPSIA, STIFFNESS, HUMANS",
    author = "Faisel Khan and Gary Mires and Maureen Macleod and Belch, {Jill J. F.}",
    year = "2010",
    doi = "10.1111/j.1549-8719.2010.00055.x",
    language = "English",
    volume = "17",
    pages = "608--614",
    journal = "Microcirculation",
    issn = "1073-9688",
    publisher = "Wiley",
    number = "8",

    }

    TY - JOUR

    T1 - Relationship Between Maternal Arterial Wave Reflection, Microvascular Function and Fetal Growth in Normal Pregnancy

    AU - Khan, Faisel

    AU - Mires, Gary

    AU - Macleod, Maureen

    AU - Belch, Jill J. F.

    PY - 2010

    Y1 - 2010

    N2 - Objective: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.Methods: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.Results: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.Conclusion: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.

    AB - Objective: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.Methods: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.Results: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.Conclusion: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.

    KW - arterial stiffness

    KW - microcirculation

    KW - fetal growth

    KW - pregnancy

    KW - ENDOTHELIAL FUNCTION

    KW - PULSE-WAVE

    KW - AORTIC PRESSURE

    KW - MEDIATED VASODILATION

    KW - CARDIOVASCULAR EVENTS

    KW - CONSENSUS DOCUMENT

    KW - AUGMENTATION INDEX

    KW - PREECLAMPSIA

    KW - STIFFNESS

    KW - HUMANS

    U2 - 10.1111/j.1549-8719.2010.00055.x

    DO - 10.1111/j.1549-8719.2010.00055.x

    M3 - Article

    VL - 17

    SP - 608

    EP - 614

    JO - Microcirculation

    JF - Microcirculation

    SN - 1073-9688

    IS - 8

    ER -