Relaxation time constant based optical coherence elastography

Duo Zhang, Chunhui Li (Lead / Corresponding author), Zhihong Huang

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)
    134 Downloads (Pure)


    This study aimed at visualizing relative relaxation time constant (RTC) in soft tissue by using optical coherence elastography (OCE). We proposed a forced vibration model as a theoretical base to express RTC using axial gradient of periodic vibration phase captured by phase sensitive optical coherence tomography (PhS-OCT). Validation of the model had been accomplished by experiments with isotropic and double-layered phantoms. A fresh chicken breast sample treated with focused ultrasound was prepared to test performance of the RTC-OCE in real tissue. All results were cross-validated with indentation test and traditional strain-based elastography. This study first utilized RTC mapping in 2D and 3D that covers the information of both elasticity and viscosity. The generated RTC mapping revealed the same mechanical difference internal sample which is correlated with conventional strain mapping. RTC mapping is potentially to be served as new biomarker for disease diagnosis in the future.

    Original languageEnglish
    Article numbere201960233
    Number of pages13
    JournalJournal of Biophotonics
    Issue number7
    Early online date13 Mar 2020
    Publication statusPublished - 30 Apr 2020


    • Kelvin-Voigt fractional derivative
    • optical coherence elastography
    • optical coherence tomography
    • relaxation time constant

    ASJC Scopus subject areas

    • General Chemistry
    • General Materials Science
    • General Biochemistry,Genetics and Molecular Biology
    • General Engineering
    • General Physics and Astronomy


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