Renal effects of angiotensin II, atrial natriuretic peptide and their interaction in man

J. J. McMurray, A. D. Struthers

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    Abstract

    There is now much evidence that atrial natriuretic peptide (ANP) is important in the control of sodium balance. There is also evidence that ANP interacts with the renin-angiotensin system at several levels. In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion. In normal male volunteers, ANP caused urinary sodium excretion to rise significantly from baseline (+80 +/- 44 mumol/min) whereas ANG II was potently antinatriuretic (-125 +/- 36 mumol/min). When ANP was administered against a nonpressor background infusion of ANG II, urinary sodium excretion rose from a new lower level (-93 +/- 22 mumol/min) to a rate not significantly different from control (-22 +/- 25 mumol/min). In contrast to that of sodium, potassium excretion and urinary volume remained significantly below baseline levels when ANP was administered against a background infusion of ANG II. These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.
    Original languageEnglish
    Pages (from-to)S59-62
    Number of pages4
    JournalJournal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    Volume5
    Issue numberS5
    Publication statusPublished - 1987

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    Atrial Natriuretic Factor
    Angiotensin II
    Kidney
    Sodium
    Electrolytes
    Water
    Renin-Angiotensin System
    Healthy Volunteers
    Potassium

    Cite this

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    abstract = "There is now much evidence that atrial natriuretic peptide (ANP) is important in the control of sodium balance. There is also evidence that ANP interacts with the renin-angiotensin system at several levels. In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion. In normal male volunteers, ANP caused urinary sodium excretion to rise significantly from baseline (+80 +/- 44 mumol/min) whereas ANG II was potently antinatriuretic (-125 +/- 36 mumol/min). When ANP was administered against a nonpressor background infusion of ANG II, urinary sodium excretion rose from a new lower level (-93 +/- 22 mumol/min) to a rate not significantly different from control (-22 +/- 25 mumol/min). In contrast to that of sodium, potassium excretion and urinary volume remained significantly below baseline levels when ANP was administered against a background infusion of ANG II. These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.",
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    T1 - Renal effects of angiotensin II, atrial natriuretic peptide and their interaction in man

    AU - McMurray, J. J.

    AU - Struthers, A. D.

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    N2 - There is now much evidence that atrial natriuretic peptide (ANP) is important in the control of sodium balance. There is also evidence that ANP interacts with the renin-angiotensin system at several levels. In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion. In normal male volunteers, ANP caused urinary sodium excretion to rise significantly from baseline (+80 +/- 44 mumol/min) whereas ANG II was potently antinatriuretic (-125 +/- 36 mumol/min). When ANP was administered against a nonpressor background infusion of ANG II, urinary sodium excretion rose from a new lower level (-93 +/- 22 mumol/min) to a rate not significantly different from control (-22 +/- 25 mumol/min). In contrast to that of sodium, potassium excretion and urinary volume remained significantly below baseline levels when ANP was administered against a background infusion of ANG II. These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.

    AB - There is now much evidence that atrial natriuretic peptide (ANP) is important in the control of sodium balance. There is also evidence that ANP interacts with the renin-angiotensin system at several levels. In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion. In normal male volunteers, ANP caused urinary sodium excretion to rise significantly from baseline (+80 +/- 44 mumol/min) whereas ANG II was potently antinatriuretic (-125 +/- 36 mumol/min). When ANP was administered against a nonpressor background infusion of ANG II, urinary sodium excretion rose from a new lower level (-93 +/- 22 mumol/min) to a rate not significantly different from control (-22 +/- 25 mumol/min). In contrast to that of sodium, potassium excretion and urinary volume remained significantly below baseline levels when ANP was administered against a background infusion of ANG II. These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.

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