Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block

Douglas H.J. Elder, Chim C. Lang, Sushma Rekhraj, Benjamin Szwejkowski, Jacob George, Stuart D. Pringle, Allan D. Struthers, Anna Maria Choy

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    Right ventricular apical pacing can cause dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function, and may be associated with adverse cardiovascular effects. The use of rennin–angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing.
    Original languageEnglish
    Pages (from-to)505-510
    Number of pages6
    JournalHeart Rhythm : the Official Journal of the Heart Rhythm Society
    Issue number4
    Publication statusPublished - Apr 2012



    • pacemaker
    • survival
    • Heart failure
    • ACE Inhibitor
    • Angiotensin receptor blockers

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