Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block

Douglas H.J. Elder; Chim C. Lang; Sushma Rekhraj; Benjamin Szwejkowski; Jacob George; Stuart D. Pringle; Allan D. Struthers; Anna Maria Choy

doi:10.1016/j.hrthm.2011.11.021

Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block

Douglas H.J. Elder, Chim C. Lang, Sushma Rekhraj, Benjamin Szwejkowski, Jacob George, Stuart D. Pringle, Allan D. Struthers, Anna Maria Choy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Right ventricular apical pacing can cause dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function, and may be associated with adverse cardiovascular effects. The use of rennin–angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing.

Original language	English
Pages (from-to)	505-510
Number of pages	6
Journal	Heart Rhythm : the Official Journal of the Heart Rhythm Society
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.hrthm.2011.11.021
Publication status	Published - Apr 2012

Keywords

pacemaker
survival
Heart failure
ACE Inhibitor
Angiotensin receptor blockers

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10.1016/j.hrthm.2011.11.021

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Elder, D. H. J., Lang, C. C., Rekhraj, S., Szwejkowski, B., George, J., Pringle, S. D., Struthers, A. D., & Choy, A. M. (2012). Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block. Heart Rhythm : the Official Journal of the Heart Rhythm Society, 9(4), 505-510. https://doi.org/10.1016/j.hrthm.2011.11.021

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title = "Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block",

abstract = "Right ventricular apical pacing can cause dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function, and may be associated with adverse cardiovascular effects. The use of rennin–angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing.",

keywords = "pacemaker, survival, Heart failure, ACE Inhibitor, Angiotensin receptor blockers",

author = "Elder, {Douglas H.J.} and Lang, {Chim C.} and Sushma Rekhraj and Benjamin Szwejkowski and Jacob George and Pringle, {Stuart D.} and Struthers, {Allan D.} and Choy, {Anna Maria}",

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doi = "10.1016/j.hrthm.2011.11.021",

language = "English",

volume = "9",

pages = "505--510",

journal = "Heart Rhythm : the Official Journal of the Heart Rhythm Society",

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Elder, DHJ, Lang, CC, Rekhraj, S, Szwejkowski, B, George, J, Pringle, SD, Struthers, AD & Choy, AM 2012, 'Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block', Heart Rhythm : the Official Journal of the Heart Rhythm Society, vol. 9, no. 4, pp. 505-510. https://doi.org/10.1016/j.hrthm.2011.11.021

Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block. / Elder, Douglas H.J.; Lang, Chim C.; Rekhraj, Sushma et al.
In: Heart Rhythm : the Official Journal of the Heart Rhythm Society, Vol. 9, No. 4, 04.2012, p. 505-510.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block

AU - Elder, Douglas H.J.

AU - Lang, Chim C.

AU - Rekhraj, Sushma

AU - Szwejkowski, Benjamin

AU - George, Jacob

AU - Pringle, Stuart D.

AU - Struthers, Allan D.

AU - Choy, Anna Maria

PY - 2012/4

Y1 - 2012/4

N2 - Right ventricular apical pacing can cause dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function, and may be associated with adverse cardiovascular effects. The use of rennin–angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing.

AB - Right ventricular apical pacing can cause dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function, and may be associated with adverse cardiovascular effects. The use of rennin–angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing.

KW - pacemaker

KW - survival

KW - Heart failure

KW - ACE Inhibitor

KW - Angiotensin receptor blockers

U2 - 10.1016/j.hrthm.2011.11.021

DO - 10.1016/j.hrthm.2011.11.021

M3 - Article

SN - 1547-5271

VL - 9

SP - 505

EP - 510

JO - Heart Rhythm : the Official Journal of the Heart Rhythm Society

JF - Heart Rhythm : the Official Journal of the Heart Rhythm Society

IS - 4

ER -

Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block

Abstract

Keywords

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