TY - JOUR
T1 - Repeated electroconvulsive stimulation impairs synaptic plasticity in the dentate gyrus in vivo but has no effect in CA1 in vitro
AU - Stewart, Caroline A.
AU - Davies, Stephen N.
N1 - This work was supported by a grant from the Wellcome Trust. The authors would like to thank Ian Reid for helpful discussion during the course of the work and for reviewing early versions of the manuscript
PY - 1996
Y1 - 1996
N2 - Repeated electroconvulsive stimulation (ECS) spaced at 48 h intervals significantly increased the synaptic response in the dentate gyms in vivo, as measured by input/output curves, and reduced the degree of long-term potentiation (LTP) obtained following high frequency stimulation. An identical course of ECS had no effect on synaptic responses recorded in the stratum radiatum of CA1 in vitro and did not impair high frequency-induced LTP. These results suggest that either ECS has a selective effect on the sub-fields of the hippocampus or that in vitro recording techniques are unsuitable for detecting the increase in synaptic efficacy produced by the treatments.
AB - Repeated electroconvulsive stimulation (ECS) spaced at 48 h intervals significantly increased the synaptic response in the dentate gyms in vivo, as measured by input/output curves, and reduced the degree of long-term potentiation (LTP) obtained following high frequency stimulation. An identical course of ECS had no effect on synaptic responses recorded in the stratum radiatum of CA1 in vitro and did not impair high frequency-induced LTP. These results suggest that either ECS has a selective effect on the sub-fields of the hippocampus or that in vitro recording techniques are unsuitable for detecting the increase in synaptic efficacy produced by the treatments.
U2 - 10.1016/0304-3940(96)12853-6
DO - 10.1016/0304-3940(96)12853-6
M3 - Article
SN - 0304-3940
VL - 213
SP - 177
EP - 180
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -