Replication licensing and cancer -: a fatal entanglement?

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    156 Citations (Scopus)

    Abstract

    Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

    Original languageEnglish
    Pages (from-to)799-806
    Number of pages8
    JournalNature Reviews Cancer
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • Animals
    • Cell Cycle Proteins
    • Cell Transformation, Neoplastic
    • DNA Damage
    • DNA Replication
    • Humans
    • Mice
    • Neoplasms
    • Nuclear Proteins

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