Replication licensing and cancer -: a fatal entanglement?

J. Julian Blow; Peter J. Gillespie

doi:10.1038/nrc2500

Replication licensing and cancer -: a fatal entanglement?

J. Julian Blow, Peter J. Gillespie

Research output: Contribution to journal › Review article › peer-review

181 Citations (Scopus)

Abstract

Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

Original language	English
Pages (from-to)	799-806
Number of pages	8
Journal	Nature Reviews Cancer
Volume	8
Issue number	10
DOIs	https://doi.org/10.1038/nrc2500
Publication status	Published - Oct 2008

Keywords

Animals
Cell Cycle Proteins
Cell Transformation, Neoplastic
DNA Damage
DNA Replication
Humans
Mice
Neoplasms
Nuclear Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrc2500

http://www.nature.com/nrc/journal/v8/n10/full/nrc2500.html

Cite this

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title = "Replication licensing and cancer -: a fatal entanglement?",

abstract = "Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.",

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AU - Blow, J. Julian

AU - Gillespie, Peter J.

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AB - Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

KW - Animals

KW - Cell Cycle Proteins

KW - Cell Transformation, Neoplastic

KW - DNA Damage

KW - DNA Replication

KW - Humans

KW - Mice

KW - Neoplasms

KW - Nuclear Proteins

U2 - 10.1038/nrc2500

DO - 10.1038/nrc2500

M3 - Review article

C2 - 18756287

SN - 1474-175X

VL - 8

SP - 799

EP - 806

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 10

ER -

Replication licensing and cancer -: a fatal entanglement?

Abstract

Keywords

UN SDGs

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