Replication licensing and cancer -: a fatal entanglement?

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    178 Citations (Scopus)


    Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

    Original languageEnglish
    Pages (from-to)799-806
    Number of pages8
    JournalNature Reviews Cancer
    Issue number10
    Publication statusPublished - Oct 2008


    • Animals
    • Cell Cycle Proteins
    • Cell Transformation, Neoplastic
    • DNA Damage
    • DNA Replication
    • Humans
    • Mice
    • Neoplasms
    • Nuclear Proteins


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