Abstract
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 799-806 |
| Number of pages | 8 |
| Journal | Nature Reviews Cancer |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- DNA Damage
- DNA Replication
- Humans
- Mice
- Neoplasms
- Nuclear Proteins
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