Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis

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• Finished

  Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

  Fairlamb, A. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator) & Wyatt, P. (Investigator)

  1/01/15 → 31/12/20

  Project: Research

  • Visceral Leishmaniasis 100%
  • Drug Discovery 99%
  • Leishmania Donovani 82%
  • Chagas Disease 74%
  • Drug Target 69%

• New Treatment for African Animal Trypanosomiasis (Joint with GalvMed)

  Gilbert, I. (Investigator), Hubbard, S. (Investigator) & Read, K. (Investigator)

  Carnegie Trust for the Universities of Scotland

  1/09/13 → 9/09/17

  Project: Research

  • Cyclin-dependent Kinase 100%
  • Diaminothiazoles 100%
  • Human African Trypanosomiasis 100%
  • Nagana 100%
  • Cyclin Dependent Kinase 100%

• A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Protein Catabolism 87%
  • Visceral Leishmaniasis 73%
  • Trypanosoma Brucei 67%
  • Ubiquitin-Conjugating Enzyme 64%