Reproductive axis ageing and fertility in men

Sarah Martins da Silva, Richard A. Anderson (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
24 Downloads (Pure)


Compared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as spermatogenesis. There is a decline in sexual function as men age, with a dramatic increase in the prevalence of erectile dysfunction after the age of 40, which is a marker for both clinically evident as well as covert coronary artery disease. Despite a quantitative decline in spermatogenesis and reduced fecundability, the male potential for fertility persists throughout adult life, however there are also increasingly recognised alterations in sperm quality and function with significant implications for offspring health. These changes are relevant to both natural and medically assisted conception.

Original languageEnglish
Pages (from-to)1109-1121
Number of pages13
JournalReviews in endocrine & metabolic disorders
Early online date2 Nov 2022
Publication statusPublished - Dec 2022


  • ART
  • Male ageing
  • Male fertility
  • Male hypogonadism
  • Reproductive axis
  • Spermatogenesis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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