Research Priorities for Precision Medicine in NAFLD

Paula Iruzubieta; Ramon Bataller; María Teresa Arias-Loste; Marco Arrese; José Luis Calleja; Graciela Castro-Narro; Kenneth Cusi; John F. Dillon; María Luz Martínez-Chantar; Miguel Mateo; Antonio Pérez; Mary E. Rinella; Manuel Romero-Gómez; Jörn M. Schattenberg; Shira Zelber-Sagi; Javier Crespo; Jeffrey V. Lazarus

doi:10.1016/j.cld.2023.01.016

Research Priorities for Precision Medicine in NAFLD

Paula Iruzubieta, Ramon Bataller, María Teresa Arias-Loste, Marco Arrese, José Luis Calleja, Graciela Castro-Narro, Kenneth Cusi, John F. Dillon, María Luz Martínez-Chantar, Miguel Mateo, Antonio Pérez, Mary E. Rinella, Manuel Romero-Gómez, Jörn M. Schattenberg, Shira Zelber-Sagi, Javier Crespo, Jeffrey V. Lazarus (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

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Abstract

NAFLD is a multisystem condition and the leading cause of chronic liver disease globally. There are no approved NAFLD-specific dugs. To advance in the prevention and treatment of NAFLD, there is a clear need to better understand the pathophysiology and genetic and environmental risk factors, identify subphenotypes, and develop personalized and precision medicine. In this review, we discuss the main NAFLD research priorities, with a particular focus on socioeconomic factors, interindividual variations, limitations of current NAFLD clinical trials, multidisciplinary models of care, and novel approaches in the management of patients with NAFLD.

Original language	English
Pages (from-to)	535-551
Number of pages	17
Journal	Clinics in Liver Disease
Volume	27
Issue number	2
Early online date	26 Feb 2023
DOIs	https://doi.org/10.1016/j.cld.2023.01.016
Publication status	Published - May 2023

Keywords

Disease phenotyping
Multidisciplinary care
NAFLD
Non-invasvie tests (NITs)
Precision medicine

ASJC Scopus subject areas

Hepatology

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Author Accepted ManuscriptAccepted author manuscript, 381 KBLicence: CC BY-NC-ND

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Iruzubieta, P., Bataller, R., Arias-Loste, M. T., Arrese, M., Calleja, J. L., Castro-Narro, G., Cusi, K., Dillon, J. F., Martínez-Chantar, M. L., Mateo, M., Pérez, A., Rinella, M. E., Romero-Gómez, M., Schattenberg, J. M., Zelber-Sagi, S., Crespo, J., & Lazarus, J. V. (2023). Research Priorities for Precision Medicine in NAFLD. Clinics in Liver Disease, 27(2), 535-551. https://doi.org/10.1016/j.cld.2023.01.016

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title = "Research Priorities for Precision Medicine in NAFLD",

abstract = "NAFLD is a multisystem condition and the leading cause of chronic liver disease globally. There are no approved NAFLD-specific dugs. To advance in the prevention and treatment of NAFLD, there is a clear need to better understand the pathophysiology and genetic and environmental risk factors, identify subphenotypes, and develop personalized and precision medicine. In this review, we discuss the main NAFLD research priorities, with a particular focus on socioeconomic factors, interindividual variations, limitations of current NAFLD clinical trials, multidisciplinary models of care, and novel approaches in the management of patients with NAFLD.",

keywords = "Disease phenotyping, Multidisciplinary care, NAFLD, Non-invasvie tests (NITs), Precision medicine",

author = "Paula Iruzubieta and Ramon Bataller and Arias-Loste, {Mar{\'i}a Teresa} and Marco Arrese and Calleja, {Jos{\'e} Luis} and Graciela Castro-Narro and Kenneth Cusi and Dillon, {John F.} and Mart{\'i}nez-Chantar, {Mar{\'i}a Luz} and Miguel Mateo and Antonio P{\'e}rez and Rinella, {Mary E.} and Manuel Romero-G{\'o}mez and Schattenberg, {J{\"o}rn M.} and Shira Zelber-Sagi and Javier Crespo and Lazarus, {Jeffrey V.}",

year = "2023",

month = may,

doi = "10.1016/j.cld.2023.01.016",

language = "English",

volume = "27",

pages = "535--551",

number = "2",

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Iruzubieta, P, Bataller, R, Arias-Loste, MT, Arrese, M, Calleja, JL, Castro-Narro, G, Cusi, K, Dillon, JF, Martínez-Chantar, ML, Mateo, M, Pérez, A, Rinella, ME, Romero-Gómez, M, Schattenberg, JM, Zelber-Sagi, S, Crespo, J & Lazarus, JV 2023, 'Research Priorities for Precision Medicine in NAFLD', Clinics in Liver Disease, vol. 27, no. 2, pp. 535-551. https://doi.org/10.1016/j.cld.2023.01.016

TY - JOUR

T1 - Research Priorities for Precision Medicine in NAFLD

AU - Iruzubieta, Paula

AU - Bataller, Ramon

AU - Arias-Loste, María Teresa

AU - Arrese, Marco

AU - Calleja, José Luis

AU - Castro-Narro, Graciela

AU - Cusi, Kenneth

AU - Dillon, John F.

AU - Martínez-Chantar, María Luz

AU - Mateo, Miguel

AU - Pérez, Antonio

AU - Rinella, Mary E.

AU - Romero-Gómez, Manuel

AU - Schattenberg, Jörn M.

AU - Zelber-Sagi, Shira

AU - Crespo, Javier

AU - Lazarus, Jeffrey V.

PY - 2023/5

Y1 - 2023/5

N2 - NAFLD is a multisystem condition and the leading cause of chronic liver disease globally. There are no approved NAFLD-specific dugs. To advance in the prevention and treatment of NAFLD, there is a clear need to better understand the pathophysiology and genetic and environmental risk factors, identify subphenotypes, and develop personalized and precision medicine. In this review, we discuss the main NAFLD research priorities, with a particular focus on socioeconomic factors, interindividual variations, limitations of current NAFLD clinical trials, multidisciplinary models of care, and novel approaches in the management of patients with NAFLD.

AB - NAFLD is a multisystem condition and the leading cause of chronic liver disease globally. There are no approved NAFLD-specific dugs. To advance in the prevention and treatment of NAFLD, there is a clear need to better understand the pathophysiology and genetic and environmental risk factors, identify subphenotypes, and develop personalized and precision medicine. In this review, we discuss the main NAFLD research priorities, with a particular focus on socioeconomic factors, interindividual variations, limitations of current NAFLD clinical trials, multidisciplinary models of care, and novel approaches in the management of patients with NAFLD.

KW - Disease phenotyping

KW - Multidisciplinary care

KW - NAFLD

KW - Non-invasvie tests (NITs)

KW - Precision medicine

U2 - 10.1016/j.cld.2023.01.016

DO - 10.1016/j.cld.2023.01.016

M3 - Review article

C2 - 37024222

AN - SCOPUS:85150393899

SN - 1089-3261

VL - 27

SP - 535

EP - 551

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 2

ER -

Research Priorities for Precision Medicine in NAFLD

Abstract

Keywords

ASJC Scopus subject areas

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