Respiratory infections and cancer

Jennifer Pollock, Chloe Hughes, James D. Chalmers (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Respiratory infection may be associated with the risk of the development of malignancy. There are well-established associations between bacterial and viral pathogens and cancer development in other organs, but fewer data are available for the risk of lung cancer in relation to respiratory pathogens. Chronic lung inflammation is associated with increased risk of cancer development and disruption of the resident lung microbiome is increasingly recognised as a risk factor for cancer development and progression. This is particularly relevant in diseases such as COPD where patients are at increased risk of lung cancer. Patients with cancer are at markedly increased risk of infection, with pneumonia accounting for more than 50% of cases of septic shock in this population. Pneumonia in patients with cancer carries a poor prognosis and may be associated with “typical” bacterial pathogens such as Streptococcus pneumoniae or opportunistic pathogens particularly in patients receiving chemotherapeutic agents. This chapter reviews the interaction between respiratory infection and cancer.
Original languageEnglish
Title of host publicationLung Diseases and Cancer
EditorsMiguel Ángel Martínez-García, Mina Gaga, Kwun M. Fong
PublisherEuropean Respiratory Society
Chapter2
Pages15-30
Number of pages16
ISBN (Electronic)9781849841559
ISBN (Print)9781849841542
DOIs
Publication statusPublished - 1 Nov 2022

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