Abstract
Introduction
Thiel embalming technique provides an ideal medium for conservation of cadavers and organs for further experimentation and testing devices for non-invasive surgery, including MR-guided Focused Ultrasound (MRgFUS). The rational of this study was to scrutinize the response of Thiel-embalmed tissue of explanted human liver and kidney on different acoustic energies.
Methods
The sonication was performed by MRgFUS (ExAblate, InSightec). After pre-planning MR-imaging and defining regions of treatment, the tissue was ablated by ultrasound with frequency of 1.15 MHz. Three spots on the liver were sonicated with acoustic energies of 253 J, 506 J and 709 J respectively (time 20 sec). The kidney was sonicated on three different locations. First spot was treated with energy of 777 J (40 sec), second spot with 863 J (40 sec). The last spot on kidney was treated 3 times consistently with acoustic energy of 777 J (120 sec).
Results
The obtained data demonstrated that sonication of the liver at ‘low’ regime induced the rise of temperature up to 59C, while the ‘medium’ and ‘high’ regimes elicited significantly higher rise up to 109C and 120C respectively. The prolonged treatment of the same spot of the liver did not lead to increase of temperature due to induction of cavitation (‘screening effect’). The same effect was observed for the kidney, where despite of continuous sonication of the same spot, the maximal temperature did not exceed 75 C. The highest temperature rise for kidney was 87 C (at 863 J).
Conclusion
The acquired data indicate that Thiel embalmed organs constitute a suitable model for testing and optimization of MRgFUS.
Thiel embalming technique provides an ideal medium for conservation of cadavers and organs for further experimentation and testing devices for non-invasive surgery, including MR-guided Focused Ultrasound (MRgFUS). The rational of this study was to scrutinize the response of Thiel-embalmed tissue of explanted human liver and kidney on different acoustic energies.
Methods
The sonication was performed by MRgFUS (ExAblate, InSightec). After pre-planning MR-imaging and defining regions of treatment, the tissue was ablated by ultrasound with frequency of 1.15 MHz. Three spots on the liver were sonicated with acoustic energies of 253 J, 506 J and 709 J respectively (time 20 sec). The kidney was sonicated on three different locations. First spot was treated with energy of 777 J (40 sec), second spot with 863 J (40 sec). The last spot on kidney was treated 3 times consistently with acoustic energy of 777 J (120 sec).
Results
The obtained data demonstrated that sonication of the liver at ‘low’ regime induced the rise of temperature up to 59C, while the ‘medium’ and ‘high’ regimes elicited significantly higher rise up to 109C and 120C respectively. The prolonged treatment of the same spot of the liver did not lead to increase of temperature due to induction of cavitation (‘screening effect’). The same effect was observed for the kidney, where despite of continuous sonication of the same spot, the maximal temperature did not exceed 75 C. The highest temperature rise for kidney was 87 C (at 863 J).
Conclusion
The acquired data indicate that Thiel embalmed organs constitute a suitable model for testing and optimization of MRgFUS.
| Original language | English |
|---|---|
| Pages (from-to) | 975 |
| Number of pages | 1 |
| Journal | Biomedizinische Technik |
| Volume | 57 |
| Issue number | SI-1 Track-C |
| DOIs | |
| Publication status | Published - 2012 |
ASJC Scopus subject areas
- Biomedical Engineering