Retinal Biomarkers Discovery for Cerebral Small Vessel Disease in an Older Population

Lucia Ballerini (Lead / Corresponding author), Ahmed E. Fetit, Stephan Wunderlich, Ruggiero Lovreglio, Sarah McGrory, Maria Valdes-Hernandez, Tom MacGillivray, Fergus N. Doubal, Ian J. Deary, Joanna Wardlaw, Emanuele Trucco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

The retinal and cerebral microvasculatures share many morphological and physiological properties. In this pilot we study the strength of the associations between morphological measurements of the retinal vasculature, obtained from fundus camera images, and of features of Small Vessel Disease (SVD), as white matter hyperintensities (WMH) and perivascular spaces (PVS), obtained from MRI brain scans. We performed a 500-trial bootstrap analysis with Regularized Gaussian linear regression on a cohort of older community-dwelling subjects (Lothian Birth Cohort 1936, N = 866) in their eighth decade. Arteriolar bifurcation coefficients, vessel tortuosity and fractal dimension predicted WMH volume in 23% of the trials. Arteriolar widths, venular bifurcation coefficients, and venular tortuosity predicted PVS in up to 99.6% of the trials.

Original languageEnglish
Title of host publicationMedical Image Understanding and Analysis - 24th Annual Conference, MIUA 2020, Proceedings
Subtitle of host publicationMedical Image Understanding and Analysis
EditorsBartlomiej W. Papiez, Ana I. L. Namburete, Mohammad Yaqub, J. Alison Noble
Place of PublicationSwitzerland
PublisherSpringer
Pages400-409
Number of pages10
ISBN (Electronic)9783030527914
ISBN (Print)9783030527907
DOIs
Publication statusPublished - 2020
EventAnnual Conference on Medical Image Understanding and Analysis - Oxford, United Kingdom
Duration: 15 Jul 202017 Jul 2020
Conference number: 24
https://link.springer.com/book/10.1007/978-3-030-52791-4

Publication series

NameCommunications in Computer and Information Science
Volume1248
ISSN (Print)1865-0929
ISSN (Electronic)1865-0937

Conference

ConferenceAnnual Conference on Medical Image Understanding and Analysis
Abbreviated titleMIUA 2020
Country/TerritoryUnited Kingdom
CityOxford
Period15/07/2017/07/20
Internet address

Keywords

  • Biomarkers
  • Retina
  • Small vessel disease

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