Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

Sarah McGrory; Lucia Ballerini; Judith A Okely; Stuart J Ritchie; Fergus N Doubal; Alex S F Doney; Baljean Dhillon; John M Starr; Thomas J MacGillivray; Emanuele Trucco; Joanna M Wardlaw; Ian J Deary

doi:10.1016/j.dadm.2019.04.012

Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

Sarah McGrory, Lucia Ballerini, Judith A Okely (Lead / Corresponding author), Stuart J Ritchie, Fergus N Doubal, Alex S F Doney, Baljean Dhillon, John M Starr, Thomas J MacGillivray, Emanuele Trucco, Joanna M Wardlaw, Ian J Deary

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Abstract

Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.

Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.

Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.

Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.

Original language	English
Pages (from-to)	500-509
Number of pages	10
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	11
Early online date	10 Jul 2019
DOIs	https://doi.org/10.1016/j.dadm.2019.04.012
Publication status	Published - 1 Dec 2019

Keywords

Cognitive change
Longitudinal study
Retinal imaging

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dadm.2019.04.012Licence: CC BY

Publisher final version
2352-8729/Ó2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/).Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 11 (2019) 500-509
Final published version, 584 KBLicence: CC BY

Cite this

McGrory, S., Ballerini, L., Okely, J. A., Ritchie, S. J., Doubal, F. N., Doney, A. S. F., Dhillon, B., Starr, J. M., MacGillivray, T. J., Trucco, E., Wardlaw, J. M., & Deary, I. J. (2019). Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 500-509. https://doi.org/10.1016/j.dadm.2019.04.012

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title = "Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936",

abstract = "Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.",

keywords = "Cognitive change, Longitudinal study, Retinal imaging",

author = "Sarah McGrory and Lucia Ballerini and Okely, {Judith A} and Ritchie, {Stuart J} and Doubal, {Fergus N} and Doney, {Alex S F} and Baljean Dhillon and Starr, {John M} and MacGillivray, {Thomas J} and Emanuele Trucco and Wardlaw, {Joanna M} and Deary, {Ian J}",

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doi = "10.1016/j.dadm.2019.04.012",

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McGrory, S, Ballerini, L, Okely, JA, Ritchie, SJ, Doubal, FN, Doney, ASF, Dhillon, B, Starr, JM, MacGillivray, TJ, Trucco, E, Wardlaw, JM & Deary, IJ 2019, 'Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 11, pp. 500-509. https://doi.org/10.1016/j.dadm.2019.04.012

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AU - McGrory, Sarah

AU - Ballerini, Lucia

AU - Okely, Judith A

AU - Ritchie, Stuart J

AU - Doubal, Fergus N

AU - Doney, Alex S F

AU - Dhillon, Baljean

AU - Starr, John M

AU - MacGillivray, Thomas J

AU - Trucco, Emanuele

AU - Wardlaw, Joanna M

AU - Deary, Ian J

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.

AB - Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.

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Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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Multi-modal Retinal Biomarkers for Vascular Dementia; Developing and Enabling Image Analysis Tools (Joint with University of Edinburgh)

Cite this

Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Multi-modal Retinal Biomarkers for Vascular Dementia; Developing and Enabling Image Analysis Tools (Joint with University of Edinburgh)

Cite this