TY - JOUR
T1 - Retinal vascular caliber changes after laser photocoagulation in diabetic retinopathy
AU - Muhiddin, Habibah Setyawati
AU - Panggalo, Idayani
AU - Ichsan, Andi Muhammad
AU - Budu, null
AU - Trucco, Emanuele
AU - Ellis, John
N1 - Funding Information:
The authors gratefully acknowledge the support of VAMPIRE team, University of Dundee, UK and support from Ninewells NHS Hospital and Medical School, Dundee, UK.
Publisher Copyright:
© 2020 Authors.
PY - 2020/12/29
Y1 - 2020/12/29
N2 - Background: Diabetic retinopathy causes vascular dilatation caused by hypoxia, whereas oxygen tension improvement leads to retinal vessels narrowing. Given that laser photocoagulation aims to increase the oxygen tension in the retina, we hypothesized that the narrowing of vessel caliber after the treatment could be possibly demonstrated. This study aimed to assess the changes in the caliber of retinal vessels before and after laser photocoagulation in diabetic retinopathy.Methods: This research was a prospective cohort study on the treatment of diabetic retinopathy by laser photocoagulation, and it was conducted at Universitas Hasanuddin Hospital, Makassar, Indonesia between November 2017-April 2018. Retinal vascular caliber changes were analyzed before and 6-8 weeks after photocoagulation in 30 diabetic eyes. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using the vessel assessment and measurement platform software for images of the retina (VAMPIRE) manual annotation tool.Results: A significant decrease of CRVE was observed after laser photocoagulation (p<0.001), but CRAE was not reduced significantly (p = 0.067). No difference was recorded between CRVE and CRAE post-laser photocoagulation (p = 0.14), implying a reduction in vein caliber toward normal in the treated eyes.Conclusions: Laser photocoagulation decreases the CRVE in diabetic retinopathy despite the absence of changes in the grade of diabetic retinopathy.
AB - Background: Diabetic retinopathy causes vascular dilatation caused by hypoxia, whereas oxygen tension improvement leads to retinal vessels narrowing. Given that laser photocoagulation aims to increase the oxygen tension in the retina, we hypothesized that the narrowing of vessel caliber after the treatment could be possibly demonstrated. This study aimed to assess the changes in the caliber of retinal vessels before and after laser photocoagulation in diabetic retinopathy.Methods: This research was a prospective cohort study on the treatment of diabetic retinopathy by laser photocoagulation, and it was conducted at Universitas Hasanuddin Hospital, Makassar, Indonesia between November 2017-April 2018. Retinal vascular caliber changes were analyzed before and 6-8 weeks after photocoagulation in 30 diabetic eyes. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using the vessel assessment and measurement platform software for images of the retina (VAMPIRE) manual annotation tool.Results: A significant decrease of CRVE was observed after laser photocoagulation (p<0.001), but CRAE was not reduced significantly (p = 0.067). No difference was recorded between CRVE and CRAE post-laser photocoagulation (p = 0.14), implying a reduction in vein caliber toward normal in the treated eyes.Conclusions: Laser photocoagulation decreases the CRVE in diabetic retinopathy despite the absence of changes in the grade of diabetic retinopathy.
KW - Diabetic retinopathy
KW - Laser photocoagulation
KW - Retinal vascular caliber
UR - http://www.scopus.com/inward/record.url?scp=85099575402&partnerID=8YFLogxK
U2 - 10.13181/mji.oa.203806
DO - 10.13181/mji.oa.203806
M3 - Article
AN - SCOPUS:85099575402
SN - 0853-1773
VL - 29
SP - 366
EP - 371
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 4
ER -
