Retinal vascular caliber changes after laser photocoagulation in diabetic retinopathy

TY - JOUR

T1 - Retinal vascular caliber changes after laser photocoagulation in diabetic retinopathy

AU - Muhiddin, Habibah Setyawati

AU - Panggalo, Idayani

AU - Ichsan, Andi Muhammad

AU - Budu, null

AU - Trucco, Emanuele

AU - Ellis, John

N1 - Funding Information: The authors gratefully acknowledge the support of VAMPIRE team, University of Dundee, UK and support from Ninewells NHS Hospital and Medical School, Dundee, UK. Publisher Copyright: © 2020 Authors.

PY - 2020/12/29

Y1 - 2020/12/29

N2 - Background: Diabetic retinopathy causes vascular dilatation caused by hypoxia, whereas oxygen tension improvement leads to retinal vessels narrowing. Given that laser photocoagulation aims to increase the oxygen tension in the retina, we hypothesized that the narrowing of vessel caliber after the treatment could be possibly demonstrated. This study aimed to assess the changes in the caliber of retinal vessels before and after laser photocoagulation in diabetic retinopathy.Methods: This research was a prospective cohort study on the treatment of diabetic retinopathy by laser photocoagulation, and it was conducted at Universitas Hasanuddin Hospital, Makassar, Indonesia between November 2017-April 2018. Retinal vascular caliber changes were analyzed before and 6-8 weeks after photocoagulation in 30 diabetic eyes. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using the vessel assessment and measurement platform software for images of the retina (VAMPIRE) manual annotation tool.Results: A significant decrease of CRVE was observed after laser photocoagulation (p<0.001), but CRAE was not reduced significantly (p = 0.067). No difference was recorded between CRVE and CRAE post-laser photocoagulation (p = 0.14), implying a reduction in vein caliber toward normal in the treated eyes.Conclusions: Laser photocoagulation decreases the CRVE in diabetic retinopathy despite the absence of changes in the grade of diabetic retinopathy.

AB - Background: Diabetic retinopathy causes vascular dilatation caused by hypoxia, whereas oxygen tension improvement leads to retinal vessels narrowing. Given that laser photocoagulation aims to increase the oxygen tension in the retina, we hypothesized that the narrowing of vessel caliber after the treatment could be possibly demonstrated. This study aimed to assess the changes in the caliber of retinal vessels before and after laser photocoagulation in diabetic retinopathy.Methods: This research was a prospective cohort study on the treatment of diabetic retinopathy by laser photocoagulation, and it was conducted at Universitas Hasanuddin Hospital, Makassar, Indonesia between November 2017-April 2018. Retinal vascular caliber changes were analyzed before and 6-8 weeks after photocoagulation in 30 diabetic eyes. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using the vessel assessment and measurement platform software for images of the retina (VAMPIRE) manual annotation tool.Results: A significant decrease of CRVE was observed after laser photocoagulation (p<0.001), but CRAE was not reduced significantly (p = 0.067). No difference was recorded between CRVE and CRAE post-laser photocoagulation (p = 0.14), implying a reduction in vein caliber toward normal in the treated eyes.Conclusions: Laser photocoagulation decreases the CRVE in diabetic retinopathy despite the absence of changes in the grade of diabetic retinopathy.

KW - Diabetic retinopathy

KW - Laser photocoagulation

KW - Retinal vascular caliber

UR - https://www.scopus.com/pages/publications/85099575402

U2 - 10.13181/mji.oa.203806

DO - 10.13181/mji.oa.203806

M3 - Article

AN - SCOPUS:85099575402

SN - 0853-1773

VL - 29

SP - 366

EP - 371

JO - Medical Journal of Indonesia

JF - Medical Journal of Indonesia

IS - 4

ER -