Retinal vessel architecture and geometry are not impaired in normal-tension glaucoma

Anne-Sophie Leveque, Magali Bouisse, José Labarere, Emanuele Trucco, Stephen Hogg, Tom MacGillivray, Florent Aptel, Christophe Chiquet (Lead / Corresponding author)

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Abstract

To investigate the associations between retinal vessel parameters and normal-tension glaucoma (NTG). We conducted a case-control study with a prospective cohort, allowing to record 23 cases of NTG. We matched NTG patient with one primary open-angle glaucoma (POAG) and one control per case by age, systemic hypertension, diabetes, and refraction. Central retinal artery equivalent (CRAE), central retinal venule equivalent (CRVE), Arteriole-To-Venule ratio (AVR), Fractal Dimension and tortuosity of the vascular network were measured using VAMPIRE software. Our sample consisted of 23 NTG, 23 POAG, and 23 control individuals, with a median age of 65 years (25-75th percentile, 56-74). No significant differences were observed in median values for CRAE (130.6 µm (25-75th percentile, 122.8; 137.0) for NTG, 128.4 µm (124.0; 132.9) for POAG, and 135.3 µm (123.3; 144.8) for controls, P = .23), CRVE (172.1 µm (160.0; 188.3), 172.8 µm (163.3; 181.6), and 175.9 µm (167.6; 188.4), P = .43), AVR (0.76, 0.75, 0.74, P = .71), tortuosity and fractal parameters across study groups. Vascular morphological parameters were not significantly associated with retinal nerve fiber layer thickness or mean deviation for the NTG and POAG groups. Our results suggest that vascular dysregulation in NTG does not modify the architecture and geometry of the retinal vessel network.

Original languageEnglish
Article number6713
Number of pages10
JournalScientific Reports
Volume13
DOIs
Publication statusPublished - 25 Apr 2023

Keywords

  • Humans
  • Aged
  • Glaucoma, Open-Angle
  • Case-Control Studies
  • Prospective Studies
  • Retinal Ganglion Cells
  • Low Tension Glaucoma
  • Retinal Vessels/diagnostic imaging
  • Intraocular Pressure

ASJC Scopus subject areas

  • General

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