Retinal vessel phenotype in patients with a history of retinal vein occlusion

Rachel Semecas, Louis Arnould, Florent Aptel, Olivier Gavard, Thibaud Mautuit, Catherine Creuzot-Garcher, Alain Bron, Tom MacGillivray, Stephen Hogg, Emmanuel Trucco, Christophe Chiquet (Lead / Corresponding author)

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Abstract

Introduction: The aim of the study was to estimate the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal analysis in the unaffected contralateral eye of patients with central or branch retinal vein occlusion (CRVO or BRVO).

Methods: Thirty-four patients suffering from CRVO, 15 suffering from BRVO, and 49 controlled matched subjects had a fundus image analyzed using the VAMPIRE software. The intraclass correlation coefficient and a Bland-Altman plot were done for the reproducibility study.

Results: There was a lack of evidence of difference between the control group and the CRVO group for CRAE (p = 0.06), CRVE (p = 0.3), and arterio-venule ratio (AVR, p = 0.6). Contralateral eyes of CRVO exhibited a significantly higher arterial and minimum arterial tortuosity values (p = 0.012), as compared with control eyes. Contralateral eyes of patients with a history of BRVO had a significantly higher CRAE (p = 0.02), AVR (p = 0.006), and minimal arterial tortuosity (p = 0.05). Fractal analysis showed that contralateral eyes of BRVO had higher values of fractal parameters (D0a, p = 0.005).

Conclusion: This study suggests that CVRO or BRVO is not triggered by the same retinal vascular phenotypes in the contralateral eye. The morphology of retinal vasculature may be associated with the occurrence of RVO, independently of known risk factors.

Original languageEnglish
Pages (from-to)722-729
Number of pages8
JournalOphthalmic Research
Volume65
Issue number6
Early online date28 Apr 2021
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Arterial diameter
  • Fractal dimension
  • Retinal image analysis
  • Retinal vein occlusion
  • Tortuosity
  • Vein diameter
  • Vessel assessment and measurement platform for images of the retina software

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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