Retinal Vessel Phenotype In Patients With Primary Open-Angle Glaucoma

Christophe Chiquet (Lead / Corresponding author), Olivier Gavard, Thomas J. MacGillivray, Alain M. Bron, Rachel Semecas, Louis Arnould, Manuel Trucco, Florent Aptel

Research output: Contribution to journalArticle

Abstract

Aims: To characterize the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity and fractal dimension (FD) - in primary open angle glaucoma (POAG) subjects.

Methods: This study included 61 POAG subjects and 61 controls matched for age, systemic hypertension and body mass index (BMI). Fundus images of the right-eye were acquired, centered on the optic nerve and the macula, using a non-mydriatic camera. CRAE, CRVE, arteriole-to-venule ratio, FD and tortuosity of the vascular network were measured using VAMPIRE software. POAG patients underwent 24.2 sita-standard visual field and peri-papillary Optical Coherence Tomography examinations. Data were expressed as median and interquartile range (75-25th percentiles).

Results: The control group was comparable to the POAG group for age, sex ratio, BMI, systemic hypertension, refraction and intraocular pressure. The mean CRAE and the mean CRVE were significantly lower in the POAG group than in the control group (150.5 (137.9; 157.1) μm vs 161.3 (154.0; 168.4) μm and 204.8 (190.1; 218.1) μm vs 233.5 (222.3; 246.9) μm, respectively; p<0.001) and for fractal parameters as well. No significant difference was found for arterial and venous tortuosity between the two groups. There was a significant correlation between CRAE and RNFL thickness (r = 0.27; p = 0.03). VAMPIRE parameters were not significantly correlated with visual field indices.

Conclusion: POAG was associated with a narrowing of arterial and venous retinal vessels, a higher arterio-venule-ratio, and lower values of fractal dimension. The relationship between CRAE and RNFL thickness needs further investigation.
Original languageEnglish
Pages (from-to)e88-e93
Number of pages6
JournalActa Ophthalmologica
Volume98
Issue number1
Early online date29 Jul 2019
DOIs
Publication statusPublished - Feb 2020

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Keywords

  • artery diameter
  • fractal dimension
  • glaucoma
  • retinal vessel
  • tortuosity
  • VAMPIRE software
  • vein diameter

Cite this

Chiquet, C., Gavard, O., MacGillivray, T. J., Bron, A. M., Semecas, R., Arnould, L., Trucco, M., & Aptel, F. (2020). Retinal Vessel Phenotype In Patients With Primary Open-Angle Glaucoma. Acta Ophthalmologica, 98(1), e88-e93. https://doi.org/10.1111/aos.14192