RETRACTED: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

Wendy Huang, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang, Oreste AcutoDan R. Littman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.

    In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.

    Original languageEnglish
    JournalNature
    Volume528
    Issue number7583
    DOIs
    Publication statusPublished - 4 Jul 2018

    Keywords

    • Animals
    • Chromatin
    • DEAD-box RNA Helicases
    • Female
    • Gene Expression Regulation
    • Hair
    • Hirschsprung Disease
    • Humans
    • Immunologic Deficiency Syndromes
    • Inflammation
    • Male
    • Mice
    • Mice, Inbred C57BL
    • Mutation
    • Nuclear Receptor Subfamily 1, Group F, Member 3
    • Organ Specificity
    • Osteochondrodysplasias
    • Protein Binding
    • RNA, Long Noncoding
    • Th17 Cells
    • Transcription, Genetic

    Fingerprint Dive into the research topics of 'RETRACTED: DDX5 and its associated lncRNA <i>Rmrp</i> modulate T<sub>H</sub>17 cell effector functions'. Together they form a unique fingerprint.

    Cite this