RETRACTED: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

Wendy Huang; Benjamin Thomas; Ryan A. Flynn; Samuel J. Gavzy; Lin Wu; Sangwon V. Kim; Jason A. Hall; Emily R. Miraldi; Charles P. Ng; Frank  Rigo; Sarah Meadows; Nina R. Montoya; Natalia G. Herrera; Ana I. Domingos; Fraydoon Rastinejad; Richard M. Myers; Frances V. Fuller-Pace; Richard Bonneau; Howard Y. Chang; Oreste Acuto; Dan R. Littman

doi:10.1038/nature16193

RETRACTED: DDX5 and its associated lncRNA Rmrp modulate T_H17 cell effector functions

Wendy Huang, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang, Oreste AcutoDan R. Littman (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Abstract

Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.

In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.

Original language	English
Journal	Nature
Volume	528
Issue number	7583
DOIs	https://doi.org/10.1038/nature16193
Publication status	Published - 4 Jul 2018

Keywords

Animals
Chromatin
DEAD-box RNA Helicases
Female
Gene Expression Regulation
Hair
Hirschsprung Disease
Humans
Immunologic Deficiency Syndromes
Inflammation
Male
Mice
Mice, Inbred C57BL
Mutation
Nuclear Receptor Subfamily 1, Group F, Member 3
Organ Specificity
Osteochondrodysplasias
Protein Binding
RNA, Long Noncoding
Th17 Cells
Transcription, Genetic

ASJC Scopus subject areas

General

Access to Document

10.1038/nature16193

https://www.nature.com/articles/s41586-018-0311-z

Cite this

Huang, W., Thomas, B., Flynn, R. A., Gavzy, S. J., Wu, L., Kim, S. V., Hall, J. A., Miraldi, E. R., Ng, C. P., Rigo, F., Meadows, S., Montoya, N. R., Herrera, N. G., Domingos, A. I., Rastinejad, F., Myers, R. M., Fuller-Pace, F. V., Bonneau, R., Chang, H. Y., ... Littman, D. R. (2018). RETRACTED: DDX5 and its associated lncRNA Rmrp modulate T_H17 cell effector functions. Nature, 528(7583). https://doi.org/10.1038/nature16193

@article{b788591f22904982b3dcfcd5362508af,

title = "RETRACTED: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions",

abstract = "Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.",

keywords = "Animals, Chromatin, DEAD-box RNA Helicases, Female, Gene Expression Regulation, Hair, Hirschsprung Disease, Humans, Immunologic Deficiency Syndromes, Inflammation, Male, Mice, Mice, Inbred C57BL, Mutation, Nuclear Receptor Subfamily 1, Group F, Member 3, Organ Specificity, Osteochondrodysplasias, Protein Binding, RNA, Long Noncoding, Th17 Cells, Transcription, Genetic",

author = "Wendy Huang and Benjamin Thomas and Flynn, {Ryan A.} and Gavzy, {Samuel J.} and Lin Wu and Kim, {Sangwon V.} and Hall, {Jason A.} and Miraldi, {Emily R.} and Ng, {Charles P.} and Frank Rigo and Sarah Meadows and Montoya, {Nina R.} and Herrera, {Natalia G.} and Domingos, {Ana I.} and Fraydoon Rastinejad and Myers, {Richard M.} and Fuller-Pace, {Frances V.} and Richard Bonneau and Chang, {Howard Y.} and Oreste Acuto and Littman, {Dan R.}",

year = "2018",

month = jul,

day = "4",

doi = "10.1038/nature16193",

language = "English",

volume = "528",

journal = "Nature",

issn = "0028-0836",

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Huang, W, Thomas, B, Flynn, RA, Gavzy, SJ, Wu, L, Kim, SV, Hall, JA, Miraldi, ER, Ng, CP, Rigo, F, Meadows, S, Montoya, NR, Herrera, NG, Domingos, AI, Rastinejad, F, Myers, RM, Fuller-Pace, FV, Bonneau, R, Chang, HY, Acuto, O & Littman, DR 2018, 'RETRACTED: DDX5 and its associated lncRNA Rmrp modulate T_H17 cell effector functions', Nature, vol. 528, no. 7583. https://doi.org/10.1038/nature16193

TY - JOUR

T1 - RETRACTED: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

AU - Huang, Wendy

AU - Thomas, Benjamin

AU - Flynn, Ryan A.

AU - Gavzy, Samuel J.

AU - Wu, Lin

AU - Kim, Sangwon V.

AU - Hall, Jason A.

AU - Miraldi, Emily R.

AU - Ng, Charles P.

AU - Rigo, Frank

AU - Meadows, Sarah

AU - Montoya, Nina R.

AU - Herrera, Natalia G.

AU - Domingos, Ana I.

AU - Rastinejad, Fraydoon

AU - Myers, Richard M.

AU - Fuller-Pace, Frances V.

AU - Bonneau, Richard

AU - Chang, Howard Y.

AU - Acuto, Oreste

AU - Littman, Dan R.

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.

AB - Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.

KW - Animals

KW - Chromatin

KW - DEAD-box RNA Helicases

KW - Female

KW - Gene Expression Regulation

KW - Hair

KW - Hirschsprung Disease

KW - Humans

KW - Immunologic Deficiency Syndromes

KW - Inflammation

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mutation

KW - Nuclear Receptor Subfamily 1, Group F, Member 3

KW - Organ Specificity

KW - Osteochondrodysplasias

KW - Protein Binding

KW - RNA, Long Noncoding

KW - Th17 Cells

KW - Transcription, Genetic

U2 - 10.1038/nature16193

DO - 10.1038/nature16193

M3 - Article

SN - 0028-0836

VL - 528

JO - Nature

JF - Nature

IS - 7583

ER -