Retraction IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Hosea Handoyo; Margaret J. Stafford; Eamon McManus; Dionissios Baltzis; Mark Peggie; Philip Cohen

doi:10.1042/BJ4570227

Retraction IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Hosea Handoyo
, Margaret J. Stafford
, Eamon McManus
, Dionissios Baltzis
, Mark Peggie
, Philip Cohen

MRC PPU

Research output: Contribution to journal › Article › peer-review

Abstract

Volume 424 (2009), pp. 109–118

This paper is being retracted at the request of the authors. Three members of the laboratory of the last-named author have tried subsequently to reproduce the result reported in Figure 2B of the paper, but have been unable to do so. Consequently, the authors no longer consider the conclusion that interleukin-1 is able to activate the full-length catalytic subunit of the protein kinase Tpl2 when it is co-transfected into IRAK1-null HEK293 cells that stably express the interleukin-1 receptor to be correct. All of the authors, apart from the first author, have agreed to this retraction.

Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen (MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK)

Original language	English
Article number	227
Journal	Biochemical Journal
Volume	457
Issue number	1
DOIs	https://doi.org/10.1042/BJ4570227
Publication status	Published - 13 Dec 2013

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10.1042/BJ4570227

1 Article

RETRACTED: IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2
Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P., 15 Nov 2009, In: Biochemical Journal. 424, p. 109-118 10 p.
Research output: Contribution to journal › Article › peer-review
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title = "Retraction IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2",

abstract = "Volume 424 (2009), pp. 109–118 This paper is being retracted at the request of the authors. Three members of the laboratory of the last-named author have tried subsequently to reproduce the result reported in Figure 2B of the paper, but have been unable to do so. Consequently, the authors no longer consider the conclusion that interleukin-1 is able to activate the full-length catalytic subunit of the protein kinase Tpl2 when it is co-transfected into IRAK1-null HEK293 cells that stably express the interleukin-1 receptor to be correct. All of the authors, apart from the first author, have agreed to this retraction. Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen (MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK)",

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AU - Peggie, Mark

AU - Cohen, Philip

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N2 - Volume 424 (2009), pp. 109–118 This paper is being retracted at the request of the authors. Three members of the laboratory of the last-named author have tried subsequently to reproduce the result reported in Figure 2B of the paper, but have been unable to do so. Consequently, the authors no longer consider the conclusion that interleukin-1 is able to activate the full-length catalytic subunit of the protein kinase Tpl2 when it is co-transfected into IRAK1-null HEK293 cells that stably express the interleukin-1 receptor to be correct. All of the authors, apart from the first author, have agreed to this retraction. Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen (MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK)

AB - Volume 424 (2009), pp. 109–118 This paper is being retracted at the request of the authors. Three members of the laboratory of the last-named author have tried subsequently to reproduce the result reported in Figure 2B of the paper, but have been unable to do so. Consequently, the authors no longer consider the conclusion that interleukin-1 is able to activate the full-length catalytic subunit of the protein kinase Tpl2 when it is co-transfected into IRAK1-null HEK293 cells that stably express the interleukin-1 receptor to be correct. All of the authors, apart from the first author, have agreed to this retraction. Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen (MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK)

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DO - 10.1042/BJ4570227

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JF - Biochemical Journal

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ER -

Retraction IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Abstract

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RETRACTED: IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

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