Retransplantation in Alport post-transplant anti-GBM disease

Gemma Browne, Paul A J Brown, Charles R V Tomson, Stewart Fleming, Andrew Allen, Richard Herriot, Charles D Pusey, Andrew J Rees, A Neil Turner

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations. The disease is severe in renal allografts and nearly always results in graft loss.
    Original languageEnglish
    Pages (from-to)675-81
    Number of pages7
    JournalKidney International
    Volume65
    Issue number2
    DOIs
    Publication statusPublished - 2004

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