Retransplantation in Alport post-transplant anti-GBM disease

Gemma Browne; Paul A J Brown; Charles R V Tomson; Stewart Fleming; Andrew Allen; Richard Herriot; Charles D Pusey; Andrew J Rees; A Neil Turner

doi:10.1111/j.1523-1755.2004.00428.x

Retransplantation in Alport post-transplant anti-GBM disease

Gemma Browne, Paul A J Brown, Charles R V Tomson, Stewart Fleming, Andrew Allen, Richard Herriot, Charles D Pusey, Andrew J Rees, A Neil Turner

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57 Citations (Scopus)

Abstract

Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations. The disease is severe in renal allografts and nearly always results in graft loss.

Original language	English
Pages (from-to)	675-81
Number of pages	7
Journal	Kidney International
Volume	65
Issue number	2
DOIs	https://doi.org/10.1111/j.1523-1755.2004.00428.x
Publication status	Published - 2004

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title = "Retransplantation in Alport post-transplant anti-GBM disease",

abstract = "Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations. The disease is severe in renal allografts and nearly always results in graft loss.",

author = "Gemma Browne and Brown, {Paul A J} and Tomson, {Charles R V} and Stewart Fleming and Andrew Allen and Richard Herriot and Pusey, {Charles D} and Rees, {Andrew J} and Turner, {A Neil}",

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AU - Browne, Gemma

AU - Brown, Paul A J

AU - Tomson, Charles R V

AU - Fleming, Stewart

AU - Allen, Andrew

AU - Herriot, Richard

AU - Pusey, Charles D

AU - Rees, Andrew J

AU - Turner, A Neil

PY - 2004

Y1 - 2004

N2 - Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations. The disease is severe in renal allografts and nearly always results in graft loss.

AB - Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations. The disease is severe in renal allografts and nearly always results in graft loss.

U2 - 10.1111/j.1523-1755.2004.00428.x

DO - 10.1111/j.1523-1755.2004.00428.x

M3 - Article

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SN - 0085-2538

VL - 65

SP - 675

EP - 681

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Retransplantation in Alport post-transplant anti-GBM disease

Abstract

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