Chemotherapy-induced peripheral neuropathy can be a major dose-limiting side effect and leave some cancer patients with long-term pain and functional disability. In some cases, the neuropathy can be so severe as to preclude further life-prolonging chemotherapy. It is important to find interventions to reduce such effects while enabling effective chemotherapy dose delivery, improved survival, and good quality of life.
Storey, D. J., Colvin, L. A., Mackean, M. J., Mitchell, R., Fleetwood-Walker, S. M., & Fallon, M. T. (2010). Reversal of Dose-Limiting Carboplatin-Induced Peripheral Neuropathy with TRPM8 Activator, Menthol, Enables Further Effective Chemotherapy Delivery. Journal of Pain and Symptom Management, 39(6), e2-e4. https://doi.org/10.1016/j.jpainsymman.2010.02.004