Reversible neural inactivation reveals hippocampal participation in several memory processes

TY - JOUR

T1 - Reversible neural inactivation reveals hippocampal participation in several memory processes

AU - Riedel, G.

AU - Micheau, J.

AU - Lam, A. G.

AU - Roloff, E. v. L.

AU - Martin, S. J.

AU - Bridge, H.

AU - de Hoz, L.

AU - Poeschel, B.

AU - McCulloch, J.

AU - Morris, R. G. M.

PY - 1999/10

Y1 - 1999/10

N2 - Studies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes-encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AMPA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.

AB - Studies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes-encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AMPA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.

KW - Animals

KW - Excitatory Amino Acid Antagonists/pharmacology

KW - Hippocampus/physiology

KW - Isoquinolines/pharmacology

KW - Male

KW - Maze Learning/physiology

KW - Memory/physiology

KW - Mental Recall/physiology

KW - Neural Inhibition/drug effects

KW - Rats

KW - Receptors, AMPA/antagonists & inhibitors

KW - Tetrazoles/pharmacology

U2 - 10.1038/13202

DO - 10.1038/13202

M3 - Article

C2 - 10491611

SN - 1097-6256

VL - 2

SP - 898

EP - 905

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 10

ER -