Rheumatoid arthritis and macrovascular disease

J. K. Alkaabi, M. Ho, R. Levison, T. Pullar, J. J. F. Belch

    Research output: Contribution to journalArticle

    114 Citations (Scopus)

    Abstract

    Objective. To measure the extent of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) compared with controls, and to evaluate any potential vascular risk factors.

    Methods. Forty RA patients were compared with an age- and sex-matched control group. Non-invasive vascular tests, i.e. carotid duplex scanning [measuring common carotid artery intima–media thickness (IMT)], ankle–brachial blood pressure index (ABPI) and QT dispersion on ECG (QTD), were performed. Traditional risk factors such as high blood pressure, blood sugar, lipids and steroid usage were assessed.

    Results. The average IMT (s.e.) in RA patients was 0.73 (0.03) mm, compared with 0.62 (0.03) mm in the control group (P=0.01, Mann–Whitney). Ten out of 40 RA patients (25%) had an ABPI < 1.0 compared with 1/40 (2.5%) in the control group (P=0.007, Fisher's). QTD was higher in RA patients; mean (s.e.) 55 (2.70) ms compared with 40 (2.50) ms in the control group (P < 0.001, t-test). There were no significant differences in the prevalence of high blood pressure, diabetes or lipid profiles. However, patients on steroids had a higher mean QTD (s.e.): 63.5 (4) compared with 48 (2.7) ms in those patients who had not received long-term steroids (P=0.003, t-test).

    Conclusion. RA patients have an increased risk of subclinical vascular disease as was shown by a higher prevalence of carotid disease, peripheral arterial disease and increased QTD. Among traditional risk factors we found a history of steroid usage to be one of the potential risk factors.

    Original languageEnglish
    Pages (from-to)292-297
    Number of pages6
    JournalRheumatology
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - Feb 2003

    Fingerprint

    Rheumatoid Arthritis
    Steroids
    Control Groups
    Blood Pressure
    Hypertension
    Lipids
    Peripheral Arterial Disease
    Common Carotid Artery
    Vascular Diseases
    Blood Vessels
    Blood Glucose
    Atherosclerosis
    Electrocardiography
    Research Design

    Cite this

    Alkaabi, J. K. ; Ho, M. ; Levison, R. ; Pullar, T. ; Belch, J. J. F. / Rheumatoid arthritis and macrovascular disease. In: Rheumatology. 2003 ; Vol. 42, No. 2. pp. 292-297.
    @article{12395a3862614155a94656569faf0896,
    title = "Rheumatoid arthritis and macrovascular disease",
    abstract = "Objective. To measure the extent of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) compared with controls, and to evaluate any potential vascular risk factors. Methods. Forty RA patients were compared with an age- and sex-matched control group. Non-invasive vascular tests, i.e. carotid duplex scanning [measuring common carotid artery intima–media thickness (IMT)], ankle–brachial blood pressure index (ABPI) and QT dispersion on ECG (QTD), were performed. Traditional risk factors such as high blood pressure, blood sugar, lipids and steroid usage were assessed. Results. The average IMT (s.e.) in RA patients was 0.73 (0.03) mm, compared with 0.62 (0.03) mm in the control group (P=0.01, Mann–Whitney). Ten out of 40 RA patients (25{\%}) had an ABPI < 1.0 compared with 1/40 (2.5{\%}) in the control group (P=0.007, Fisher's). QTD was higher in RA patients; mean (s.e.) 55 (2.70) ms compared with 40 (2.50) ms in the control group (P < 0.001, t-test). There were no significant differences in the prevalence of high blood pressure, diabetes or lipid profiles. However, patients on steroids had a higher mean QTD (s.e.): 63.5 (4) compared with 48 (2.7) ms in those patients who had not received long-term steroids (P=0.003, t-test). Conclusion. RA patients have an increased risk of subclinical vascular disease as was shown by a higher prevalence of carotid disease, peripheral arterial disease and increased QTD. Among traditional risk factors we found a history of steroid usage to be one of the potential risk factors.",
    author = "Alkaabi, {J. K.} and M. Ho and R. Levison and T. Pullar and Belch, {J. J. F.}",
    year = "2003",
    month = "2",
    doi = "10.1093/rheumatology/keg083",
    language = "English",
    volume = "42",
    pages = "292--297",
    journal = "Rheumatology",
    issn = "1462-0324",
    publisher = "Oxford University Press",
    number = "2",

    }

    Alkaabi, JK, Ho, M, Levison, R, Pullar, T & Belch, JJF 2003, 'Rheumatoid arthritis and macrovascular disease', Rheumatology, vol. 42, no. 2, pp. 292-297. https://doi.org/10.1093/rheumatology/keg083

    Rheumatoid arthritis and macrovascular disease. / Alkaabi, J. K.; Ho, M.; Levison, R.; Pullar, T.; Belch, J. J. F.

    In: Rheumatology, Vol. 42, No. 2, 02.2003, p. 292-297.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Rheumatoid arthritis and macrovascular disease

    AU - Alkaabi, J. K.

    AU - Ho, M.

    AU - Levison, R.

    AU - Pullar, T.

    AU - Belch, J. J. F.

    PY - 2003/2

    Y1 - 2003/2

    N2 - Objective. To measure the extent of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) compared with controls, and to evaluate any potential vascular risk factors. Methods. Forty RA patients were compared with an age- and sex-matched control group. Non-invasive vascular tests, i.e. carotid duplex scanning [measuring common carotid artery intima–media thickness (IMT)], ankle–brachial blood pressure index (ABPI) and QT dispersion on ECG (QTD), were performed. Traditional risk factors such as high blood pressure, blood sugar, lipids and steroid usage were assessed. Results. The average IMT (s.e.) in RA patients was 0.73 (0.03) mm, compared with 0.62 (0.03) mm in the control group (P=0.01, Mann–Whitney). Ten out of 40 RA patients (25%) had an ABPI < 1.0 compared with 1/40 (2.5%) in the control group (P=0.007, Fisher's). QTD was higher in RA patients; mean (s.e.) 55 (2.70) ms compared with 40 (2.50) ms in the control group (P < 0.001, t-test). There were no significant differences in the prevalence of high blood pressure, diabetes or lipid profiles. However, patients on steroids had a higher mean QTD (s.e.): 63.5 (4) compared with 48 (2.7) ms in those patients who had not received long-term steroids (P=0.003, t-test). Conclusion. RA patients have an increased risk of subclinical vascular disease as was shown by a higher prevalence of carotid disease, peripheral arterial disease and increased QTD. Among traditional risk factors we found a history of steroid usage to be one of the potential risk factors.

    AB - Objective. To measure the extent of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) compared with controls, and to evaluate any potential vascular risk factors. Methods. Forty RA patients were compared with an age- and sex-matched control group. Non-invasive vascular tests, i.e. carotid duplex scanning [measuring common carotid artery intima–media thickness (IMT)], ankle–brachial blood pressure index (ABPI) and QT dispersion on ECG (QTD), were performed. Traditional risk factors such as high blood pressure, blood sugar, lipids and steroid usage were assessed. Results. The average IMT (s.e.) in RA patients was 0.73 (0.03) mm, compared with 0.62 (0.03) mm in the control group (P=0.01, Mann–Whitney). Ten out of 40 RA patients (25%) had an ABPI < 1.0 compared with 1/40 (2.5%) in the control group (P=0.007, Fisher's). QTD was higher in RA patients; mean (s.e.) 55 (2.70) ms compared with 40 (2.50) ms in the control group (P < 0.001, t-test). There were no significant differences in the prevalence of high blood pressure, diabetes or lipid profiles. However, patients on steroids had a higher mean QTD (s.e.): 63.5 (4) compared with 48 (2.7) ms in those patients who had not received long-term steroids (P=0.003, t-test). Conclusion. RA patients have an increased risk of subclinical vascular disease as was shown by a higher prevalence of carotid disease, peripheral arterial disease and increased QTD. Among traditional risk factors we found a history of steroid usage to be one of the potential risk factors.

    U2 - 10.1093/rheumatology/keg083

    DO - 10.1093/rheumatology/keg083

    M3 - Article

    C2 - 12595625

    VL - 42

    SP - 292

    EP - 297

    JO - Rheumatology

    JF - Rheumatology

    SN - 1462-0324

    IS - 2

    ER -