Rhodiola rosea L. from golden root to green cell factories

Andrey S. Marchev (Lead / Corresponding author), Albena T. Dinkova-Kostova, Zsuzsanna György, Iman Mirmazloum, Ina Y. Aneva, Milen I. Georgiev

    Research output: Contribution to journalArticle

    16 Citations (Scopus)
    369 Downloads (Pure)

    Abstract

    Rhodiola rosea L. is a worldwide popular plant with adaptogenic activities that have been and currently are exploited in the traditional medicine of many countries, as well as, examined in a number of clinical trials. More than 140 chemical structures have been identified which belong to several natural product classes, including phenylpropanoid glycosides, phenylethanoids, flavonoids and essential oils, and are mainly stored in the rhizomes and the roots of the plant. A number of mechanisms contribute to the adaptogenic activities of R. rosea preparations and its phytochemical constituents. Among them, the intrinsic inducible mammalian stress responses and their effector proteins, such as heat shock protein 70 (Hsp70), are the most prominent. Due to its popular medicinal use, which has led to depletion of its natural habitats, R. rosea is now considered as endangered in most parts of the world. Conservation, cultivation and micropropagation are all implemented as potential preservation strategies. A number of in vitro systems of R. rosea are being developed as sources of pharmaceutically valuable secondary metabolites. These are greatly facilitated by advances in elucidation of the biosynthetic pathways and the enzymes, which catalyse the production of these secondary metabolites in the plant. In addition, biotechnological approaches show promise towards achieving sustainable production of R. rosea secondary metabolites.

    Original languageEnglish
    Pages (from-to)515-536
    Number of pages22
    JournalPhytochemistry Reviews
    Volume15
    Issue number4
    Early online date13 Jan 2016
    DOIs
    Publication statusPublished - Aug 2016

    Keywords

    • Clinical trials
    • In vitro systems
    • Medicinal use
    • Roseroot
    • Secondary metabolites

    Fingerprint Dive into the research topics of 'Rhodiola rosea L. from golden root to green cell factories'. Together they form a unique fingerprint.

  • Cite this

    Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y., & Georgiev, M. I. (2016). Rhodiola rosea L. from golden root to green cell factories. Phytochemistry Reviews, 15(4), 515-536. https://doi.org/10.1007/s11101-016-9453-5