Ribozymes and the mechanisms that underlie RNA catalysis

Timothy J. Wilson, Yijin Liu, David M J Lilley (Lead / Corresponding author)

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalFrontiers of Chemical Science and Engineering
Volume10
Issue number2
Early online date5 Feb 2016
DOIs
Publication statusPublished - Jun 2016

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Catalytic RNA
RNA
Catalysis
Coenzymes
Acids
Guanine
Adenine
Metal ions
Molecules

Keywords

  • catalytic mechanism
  • RNA catalysis
  • RNA structure

Cite this

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AB - Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes. [Figure not available: see fulltext.]

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KW - RNA structure

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