TY - JOUR
T1 - Risk factors for aspiration in community-acquired pneumonia
T2 - Analysis of a hospitalized UK cohort
AU - Taylor, Joanne K.
AU - Fleming, Gillian B.
AU - Singanayagam, Aran
AU - Hill, Adam T.
AU - Chalmers, James D.
PY - 2013
Y1 - 2013
N2 - Background There is a move toward finding clinically useful "phenotypes" in community-acquired pneumonia: groups of patients displaying distinct clinical characteristics, microbiology, and prognosis. Aspiration pneumonia is an intuitive clinical phenotype; however, to date there are no recognized diagnostic criteria, and data regarding outcomes in suspected aspiration are limited. Methods An observational study of 1348 patients hospitalized with community-acquired pneumonia in the United Kingdom examined both short- and long-term outcomes for patients at risk of aspiration pneumonia. Patients were defined as "at risk" in the presence of chronic neurologic disorders, esophageal disorders and dysphagia, impaired conscious level, vomiting, or witnessed aspiration. The primary outcome was 30-day mortality. Secondary outcomes included 1-year mortality, readmissions, and recurrent pneumonia within 1 year. Results Some 13.8% of the cohort were classified as "at risk of aspiration." These patients were older (median age, 74 years [interquartile range, 60-84] vs 66 years [interquartile range, 49-77]; P
AB - Background There is a move toward finding clinically useful "phenotypes" in community-acquired pneumonia: groups of patients displaying distinct clinical characteristics, microbiology, and prognosis. Aspiration pneumonia is an intuitive clinical phenotype; however, to date there are no recognized diagnostic criteria, and data regarding outcomes in suspected aspiration are limited. Methods An observational study of 1348 patients hospitalized with community-acquired pneumonia in the United Kingdom examined both short- and long-term outcomes for patients at risk of aspiration pneumonia. Patients were defined as "at risk" in the presence of chronic neurologic disorders, esophageal disorders and dysphagia, impaired conscious level, vomiting, or witnessed aspiration. The primary outcome was 30-day mortality. Secondary outcomes included 1-year mortality, readmissions, and recurrent pneumonia within 1 year. Results Some 13.8% of the cohort were classified as "at risk of aspiration." These patients were older (median age, 74 years [interquartile range, 60-84] vs 66 years [interquartile range, 49-77]; P
UR - http://www.scopus.com/inward/record.url?scp=84886419531&partnerID=8YFLogxK
U2 - 10.1016/j.amjmed.2013.07.012
DO - 10.1016/j.amjmed.2013.07.012
M3 - Article
C2 - 24054176
AN - SCOPUS:84886419531
SN - 0002-9343
VL - 126
SP - 995
EP - 1001
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 11
ER -