Risk factors of late intraocular Lens displacement: A multi-national study

Chimwemwe Chipeta; Jufen Zhang; Max Davidson; Ahmed B. Sallam; Joseph Toma; Beatrice Gallo; Evgenia Anikina; Amanda Ie; Mayuresh Naik; Kanmin Xue; Omkaar Sivanesan; Sonali Tarafdar; Shane Whitlow; Danny Mitry; Mandeep Singh Bindra; Marta Latasiewicz; Loic Sermeus; Kai Januschowski; Andrew Davies; Ken Kawamoto; Rabia Bourkiza; Amee Patel; Kurt Spiteri-Cornish; Virginija Vilkelyte; Conor Ramsden; Francesco Maria D’Alterio; Maria T. Sandinha; Stratos Gotzaridis; Shahina Pardhan; Aman Chandra

doi:10.1177/11206721251358006

Risk factors of late intraocular Lens displacement: A multi-national study

Chimwemwe Chipeta (Lead / Corresponding author), Jufen Zhang, Max Davidson, Ahmed B. Sallam, Joseph Toma, Beatrice Gallo, Evgenia Anikina, Amanda Ie, Mayuresh Naik, Kanmin Xue, Omkaar Sivanesan, Sonali Tarafdar, Shane Whitlow, Danny Mitry, Mandeep Singh Bindra, Marta Latasiewicz, Loic Sermeus, Kai Januschowski, Andrew Davies, Ken KawamotoRabia Bourkiza, Amee Patel, Kurt Spiteri-Cornish, Virginija Vilkelyte, Conor Ramsden, Francesco Maria D’Alterio, Maria T. Sandinha, Stratos Gotzaridis, Shahina Pardhan, Aman Chandra

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To examine potential risk factors of late intraocular lens displacement (LIOLD); a rare complication of cataract surgery believed to be due to progressive zonular insufficiency which is often managed with pars plana vitrectomy (PPV) and intraocular lens (IOL) exchange. Setting: 16 centers across the UK, Germany and Greece Design: Retrospective case control study Methods: Cases of LIOLD occurring between June 2018 and January 2023 were identified. Demographics, biometry data, previous medical and ocular history were interrogated and multivariate logistic regression was performed. Results: 434 eyes experiencing LIOLD were identified. 20,321 eyes not experiencing LIOLD during the same period formed the control group. Following multivariate analysis, YAG capsulotomy (OR 17.17, 95% CI 12.44–23.70, p < 0.001), pseudoexfoliation (OR 15.63, 95% CI 10.78–22.64, p < 0.001), complicated cataract surgery (OR 17.60, 95% CI 12.94–23.95, p < 0.001), previous PPV (OR 4.86, 95% CI 3.50–6.75, p < 0.001), younger age at cataract surgery (OR 0.94, 95% CI 0.93–0.95, p < 0.001) and axial myopia (OR 1.16, 95% CI 1.09–1.24, p < 0.001) were identified as risk factors. Female sex was associated with reduced risk (OR 0.64, 95% CI 0.51–0.80, p < 0.001). Patients having cataract surgery under 60 years had an increased risk (40 years OR 2.90, 30 years OR 4.92). Conclusion: Risk factors are known to vary by geographical location and our study being the first multinational study provides a significant contribution. Future studies may look at prevention for at-risk individuals and compare outcomes of different IOL fixation techniques.

Original language	English
Article number	11206721251358006
Journal	European Journal of Ophthalmology
Early online date	17 Jul 2025
DOIs	https://doi.org/10.1177/11206721251358006
Publication status	E-pub ahead of print - 17 Jul 2025

Keywords

cataract surgery
late intraocular lens dislocations
Zonule

ASJC Scopus subject areas

Ophthalmology

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10.1177/11206721251358006

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Chipeta, C., Zhang, J., Davidson, M., Sallam, A. B., Toma, J., Gallo, B., Anikina, E., Ie, A., Naik, M., Xue, K., Sivanesan, O., Tarafdar, S., Whitlow, S., Mitry, D., Bindra, M. S., Latasiewicz, M., Sermeus, L., Januschowski, K., Davies, A., ... Chandra, A. (2025). Risk factors of late intraocular Lens displacement: A multi-national study. European Journal of Ophthalmology, Article 11206721251358006. Advance online publication. https://doi.org/10.1177/11206721251358006

@article{d0b57280d2934804b27b076c1005cd3a,

title = "Risk factors of late intraocular Lens displacement: A multi-national study",

abstract = "Purpose: To examine potential risk factors of late intraocular lens displacement (LIOLD); a rare complication of cataract surgery believed to be due to progressive zonular insufficiency which is often managed with pars plana vitrectomy (PPV) and intraocular lens (IOL) exchange. Setting: 16 centers across the UK, Germany and Greece Design: Retrospective case control study Methods: Cases of LIOLD occurring between June 2018 and January 2023 were identified. Demographics, biometry data, previous medical and ocular history were interrogated and multivariate logistic regression was performed. Results: 434 eyes experiencing LIOLD were identified. 20,321 eyes not experiencing LIOLD during the same period formed the control group. Following multivariate analysis, YAG capsulotomy (OR 17.17, 95\% CI 12.44–23.70, p < 0.001), pseudoexfoliation (OR 15.63, 95\% CI 10.78–22.64, p < 0.001), complicated cataract surgery (OR 17.60, 95\% CI 12.94–23.95, p < 0.001), previous PPV (OR 4.86, 95\% CI 3.50–6.75, p < 0.001), younger age at cataract surgery (OR 0.94, 95\% CI 0.93–0.95, p < 0.001) and axial myopia (OR 1.16, 95\% CI 1.09–1.24, p < 0.001) were identified as risk factors. Female sex was associated with reduced risk (OR 0.64, 95\% CI 0.51–0.80, p < 0.001). Patients having cataract surgery under 60 years had an increased risk (40 years OR 2.90, 30 years OR 4.92). Conclusion: Risk factors are known to vary by geographical location and our study being the first multinational study provides a significant contribution. Future studies may look at prevention for at-risk individuals and compare outcomes of different IOL fixation techniques.",

keywords = "cataract surgery, late intraocular lens dislocations, Zonule",

author = "Chimwemwe Chipeta and Jufen Zhang and Max Davidson and Sallam, \{Ahmed B.\} and Joseph Toma and Beatrice Gallo and Evgenia Anikina and Amanda Ie and Mayuresh Naik and Kanmin Xue and Omkaar Sivanesan and Sonali Tarafdar and Shane Whitlow and Danny Mitry and Bindra, \{Mandeep Singh\} and Marta Latasiewicz and Loic Sermeus and Kai Januschowski and Andrew Davies and Ken Kawamoto and Rabia Bourkiza and Amee Patel and Kurt Spiteri-Cornish and Virginija Vilkelyte and Conor Ramsden and D{\textquoteright}Alterio, \{Francesco Maria\} and Sandinha, \{Maria T.\} and Stratos Gotzaridis and Shahina Pardhan and Aman Chandra",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025",

year = "2025",

month = jul,

day = "17",

doi = "10.1177/11206721251358006",

language = "English",

}

Chipeta, C, Zhang, J, Davidson, M, Sallam, AB, Toma, J, Gallo, B, Anikina, E, Ie, A, Naik, M, Xue, K, Sivanesan, O , Tarafdar, S, Whitlow, S, Mitry, D, Bindra, MS, Latasiewicz, M, Sermeus, L, Januschowski, K, Davies, A, Kawamoto, K, Bourkiza, R, Patel, A, Spiteri-Cornish, K, Vilkelyte, V, Ramsden, C, D’Alterio, FM, Sandinha, MT, Gotzaridis, S, Pardhan, S & Chandra, A 2025, 'Risk factors of late intraocular Lens displacement: A multi-national study', European Journal of Ophthalmology. https://doi.org/10.1177/11206721251358006

TY - JOUR

T1 - Risk factors of late intraocular Lens displacement

T2 - A multi-national study

AU - Chipeta, Chimwemwe

AU - Zhang, Jufen

AU - Davidson, Max

AU - Sallam, Ahmed B.

AU - Toma, Joseph

AU - Gallo, Beatrice

AU - Anikina, Evgenia

AU - Ie, Amanda

AU - Naik, Mayuresh

AU - Xue, Kanmin

AU - Sivanesan, Omkaar

AU - Tarafdar, Sonali

AU - Whitlow, Shane

AU - Mitry, Danny

AU - Bindra, Mandeep Singh

AU - Latasiewicz, Marta

AU - Sermeus, Loic

AU - Januschowski, Kai

AU - Davies, Andrew

AU - Kawamoto, Ken

AU - Bourkiza, Rabia

AU - Patel, Amee

AU - Spiteri-Cornish, Kurt

AU - Vilkelyte, Virginija

AU - Ramsden, Conor

AU - D’Alterio, Francesco Maria

AU - Sandinha, Maria T.

AU - Gotzaridis, Stratos

AU - Pardhan, Shahina

AU - Chandra, Aman

PY - 2025/7/17

Y1 - 2025/7/17

N2 - Purpose: To examine potential risk factors of late intraocular lens displacement (LIOLD); a rare complication of cataract surgery believed to be due to progressive zonular insufficiency which is often managed with pars plana vitrectomy (PPV) and intraocular lens (IOL) exchange. Setting: 16 centers across the UK, Germany and Greece Design: Retrospective case control study Methods: Cases of LIOLD occurring between June 2018 and January 2023 were identified. Demographics, biometry data, previous medical and ocular history were interrogated and multivariate logistic regression was performed. Results: 434 eyes experiencing LIOLD were identified. 20,321 eyes not experiencing LIOLD during the same period formed the control group. Following multivariate analysis, YAG capsulotomy (OR 17.17, 95% CI 12.44–23.70, p < 0.001), pseudoexfoliation (OR 15.63, 95% CI 10.78–22.64, p < 0.001), complicated cataract surgery (OR 17.60, 95% CI 12.94–23.95, p < 0.001), previous PPV (OR 4.86, 95% CI 3.50–6.75, p < 0.001), younger age at cataract surgery (OR 0.94, 95% CI 0.93–0.95, p < 0.001) and axial myopia (OR 1.16, 95% CI 1.09–1.24, p < 0.001) were identified as risk factors. Female sex was associated with reduced risk (OR 0.64, 95% CI 0.51–0.80, p < 0.001). Patients having cataract surgery under 60 years had an increased risk (40 years OR 2.90, 30 years OR 4.92). Conclusion: Risk factors are known to vary by geographical location and our study being the first multinational study provides a significant contribution. Future studies may look at prevention for at-risk individuals and compare outcomes of different IOL fixation techniques.

AB - Purpose: To examine potential risk factors of late intraocular lens displacement (LIOLD); a rare complication of cataract surgery believed to be due to progressive zonular insufficiency which is often managed with pars plana vitrectomy (PPV) and intraocular lens (IOL) exchange. Setting: 16 centers across the UK, Germany and Greece Design: Retrospective case control study Methods: Cases of LIOLD occurring between June 2018 and January 2023 were identified. Demographics, biometry data, previous medical and ocular history were interrogated and multivariate logistic regression was performed. Results: 434 eyes experiencing LIOLD were identified. 20,321 eyes not experiencing LIOLD during the same period formed the control group. Following multivariate analysis, YAG capsulotomy (OR 17.17, 95% CI 12.44–23.70, p < 0.001), pseudoexfoliation (OR 15.63, 95% CI 10.78–22.64, p < 0.001), complicated cataract surgery (OR 17.60, 95% CI 12.94–23.95, p < 0.001), previous PPV (OR 4.86, 95% CI 3.50–6.75, p < 0.001), younger age at cataract surgery (OR 0.94, 95% CI 0.93–0.95, p < 0.001) and axial myopia (OR 1.16, 95% CI 1.09–1.24, p < 0.001) were identified as risk factors. Female sex was associated with reduced risk (OR 0.64, 95% CI 0.51–0.80, p < 0.001). Patients having cataract surgery under 60 years had an increased risk (40 years OR 2.90, 30 years OR 4.92). Conclusion: Risk factors are known to vary by geographical location and our study being the first multinational study provides a significant contribution. Future studies may look at prevention for at-risk individuals and compare outcomes of different IOL fixation techniques.

KW - cataract surgery

KW - late intraocular lens dislocations

KW - Zonule

UR - https://www.scopus.com/pages/publications/105012584569

U2 - 10.1177/11206721251358006

DO - 10.1177/11206721251358006

M3 - Article

C2 - 40676896

AN - SCOPUS:105012584569

SN - 1120-6721

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

M1 - 11206721251358006

ER -

Risk factors of late intraocular Lens displacement: A multi-national study

Abstract

Keywords

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