Risk of hospitalization and death following prostate biopsy in Scotland

David H. Brewster, Colin M. Fischbacher, J. Nolan, S. Nowell, D. Redpath, Ghulam Nabi

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    13 Citations (Scopus)
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    Objective: To investigate the risk of hospitalization and death following prostate biopsy.

    Study design: Retrospective cohort study.

    Methods: Our study population comprised 10,285 patients with a record of first ever prostate biopsy between 2009 and 2013 on computerized acute hospital discharge or outpatient records covering Scotland. Using the general population as a comparison group, expected numbers of admissions/deaths were derived by applying age-, sex-, deprivation category-, and calendar year-specific rates of hospital admissions/deaths to the study population. Indirectly standardized hospital admission ratios (SHRs) and mortality ratios (SMRs) were calculated by dividing the observed numbers of admissions/deaths by expected numbers.

    Results: Compared with background rates, patients were more likely to be admitted to hospital within 30 days (SHR 2.7; 95% confidence interval 2.4, 2.9) and 120 days (SHR 4.0; 3.8, 4.1) of biopsy. Patients with prior co-morbidity had higher SHRs. The risk of death within 30 days of biopsy was not increased significantly (SMR 1.6; 0.9, 2.7), but within 120 days, the risk of death was significantly higher than expected (SMR 1.9; 1.5, 2.4). The risk of death increased with age and tended to be higher among patients with prior co-morbidity. Overall risks of hospitalization and of death up to 120 days were increased both in men diagnosed and those not diagnosed with prostate cancer.

    Conclusions: Higher rates of adverse events in older patients and patients with prior co-morbidity emphasizes the need for careful patient selection for prostate biopsy and justifies ongoing efforts to minimize the risk of complications.
    Original languageEnglish
    Pages (from-to)102-110
    Number of pages9
    JournalPublic Health
    Early online date31 Oct 2016
    Publication statusPublished - Jan 2017


    • Biopsy
    • Complications
    • Hospitalization
    • Morbidity
    • Mortality
    • Prostrate


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