Robotic or open radical cystectomy, which is safer? a systematic review and meta-analysis of comparative studies

Hiro Ishii, Bhavan Prasad Rai (Lead / Corresponding author), Jens-Uwe Stolzenburg, Pradeep Bose, Piotr L. Chlosta, Bhaskar K. Somani, Ghulam Nabi, Hasan Abdur Rahman Qazi, Krishnamoorthy Rajbabu, Howard Kynaston, Omar M. Aboumarzouk

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)


    Robotic radical cystectomy (RRC) has been growing in popularity across the world as a treatment option for bladder cancer.

    Objectives: To compare early surgical outcomes for RRC and open radical cystectomy (ORC) with an emphasis on complications and postoperative mortality rates.

    Methods: Evidence Acquisition: A literature review was conducted from 2000 to 2013, including studies comparing RRC and ORC. The main outcome measures analyzed were the complications and mortality rates, in addition to patient demographics, pathological parameters, operating time, estimated blood loss (EBL), transfusion rates, and type of urinary diversion. A meta-analysis was conducted. For continuous data, the Mantel-Haenszel chi-square test was used, and for dichotomous data, inverse variance was used and each expressed as risk ratio with 95% CI.

    Results: In total, 748 patients were included, 461 patients in the robotic group and 287 patients in the open group (seven studies). There were no significant differences in the demographic parameters of the two groups, except for age (age: p=0.03). There was no difference in the number of muscle-invasive diseases: p=0.47. No difference in positive surgical margin rates (p=0.21).

    Primary Outcomes: The overall (p=0.32) and lower grade (Clavien I-II) (p=0.10) complication rates between the two cohorts did not achieve statistical significance. The high-grade (Clavien III-IV) (p=0.007) complication rates in the ORC group were significantly higher. The mortality rate (Clavien V) was higher in the ORC group (2.2%) compared with the RRC group (0.35%) and this did achieve statistical significance on a meta-analysis (p=0.04).

    Secondary Outcomes: The EBL and transfusion rates were statistically significantly lower in the RRC cohort (p<0.00001). The operating time was statistically significantly higher in the RRC cohort (p<0.00001). There was no statistically significant difference in the margin positivity between the two cohorts (p=0.08).

    Conclusion: In early experience, RRC appears to be feasible and a safe alternative to the ORC. RRC appears to have lower high-grade complications and mortality rates compared with the open approach. Although these results are promising, the authors would suggest caution while interpreting these results due to concerns with methodological flaws in the included studies in this review.

    Original languageEnglish
    Pages (from-to)1215-1223
    Number of pages9
    JournalJournal of Endourology
    Issue number10
    Publication statusPublished - 2 Oct 2014

    ASJC Scopus subject areas

    • Urology


    Dive into the research topics of 'Robotic or open radical cystectomy, which is safer? a systematic review and meta-analysis of comparative studies'. Together they form a unique fingerprint.

    Cite this