Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

Christos Themistokleous; Enrico Bagnoli; Ramaa Parulekar; Miratul M K Muqit

doi:10.1016/j.jmb.2023.168144

Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

Christos Themistokleous, Enrico Bagnoli, Ramaa Parulekar, Miratul M K Muqit (Lead / Corresponding author)

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Abstract

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.

Original language	English
Article number	168144
Number of pages	26
Journal	Journal of Molecular Biology
Volume	435
Issue number	12
Early online date	13 May 2023
DOIs	https://doi.org/10.1016/j.jmb.2023.168144
Publication status	Published - 15 Jun 2023

Keywords

autophagy
Parkinson’s disease
mitophagy
PINK1
Parkin

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10.1016/j.jmb.2023.168144Licence: CC BY

Final Published VersionFinal published version, 1.78 MBLicence: CC BY

Cite this

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title = "Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders",

abstract = "The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.",

keywords = "autophagy, Parkinson{\textquoteright}s disease, mitophagy, PINK1, Parkin",

author = "Christos Themistokleous and Enrico Bagnoli and Ramaa Parulekar and {M K Muqit}, Miratul",

note = "Funding Information: The research of the authors is supported by a Wellcome Trust Senior Research Fellowship in Clinical Science (210753/Z/18/Z); Michael J. Fox Foundation (MJFF) for Parkinson{\textquoteright}s disease research; Aligning Science Across Parkinson's (ASAP) initiative. MJFF administers the grant (ASAP-000463) on behalf of ASAP and itself; the EMBO Young Investigator Programme (EMBO-YIP) and the pharmaceutical companies supporting the Division of Signal Transduction Therapy Unit (Boehringer-Ingelheim, GlaxoSmithKline, Merck KGaA). Copyright: {\textcopyright} 2023. Published by Elsevier Ltd.",

year = "2023",

month = jun,

day = "15",

doi = "10.1016/j.jmb.2023.168144",

language = "English",

volume = "435",

journal = "Journal of Molecular Biology",

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TY - JOUR

T1 - Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

AU - Themistokleous, Christos

AU - Bagnoli, Enrico

AU - Parulekar, Ramaa

AU - M K Muqit, Miratul

N1 - Funding Information: The research of the authors is supported by a Wellcome Trust Senior Research Fellowship in Clinical Science (210753/Z/18/Z); Michael J. Fox Foundation (MJFF) for Parkinson’s disease research; Aligning Science Across Parkinson's (ASAP) initiative. MJFF administers the grant (ASAP-000463) on behalf of ASAP and itself; the EMBO Young Investigator Programme (EMBO-YIP) and the pharmaceutical companies supporting the Division of Signal Transduction Therapy Unit (Boehringer-Ingelheim, GlaxoSmithKline, Merck KGaA). Copyright: © 2023. Published by Elsevier Ltd.

PY - 2023/6/15

Y1 - 2023/6/15

N2 - The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.

AB - The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.

KW - autophagy

KW - Parkinson’s disease

KW - mitophagy

KW - PINK1

KW - Parkin

UR - http://www.scopus.com/inward/record.url?scp=85156181979&partnerID=8YFLogxK

U2 - 10.1016/j.jmb.2023.168144

DO - 10.1016/j.jmb.2023.168144

M3 - Review article

C2 - 37182812

SN - 0022-2836

VL - 435

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 12

M1 - 168144

ER -

Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

Abstract

Keywords

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Other files and links

Fingerprint

ASAP - Mapping the LRRK2 Signalling Pathway and its Interplay with other Parkinson's Disease Components

Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

Cite this

Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

ASAP - Mapping the LRRK2 Signalling Pathway and its Interplay with other Parkinson's Disease Components

Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

Cite this