Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders

Christos Themistokleous, Enrico Bagnoli, Ramaa Parulekar, Miratul M K Muqit (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)
115 Downloads (Pure)

Abstract

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.

Original languageEnglish
Article number168144
Number of pages26
JournalJournal of Molecular Biology
Volume435
Issue number12
Early online date13 May 2023
DOIs
Publication statusPublished - 15 Jun 2023

Keywords

  • autophagy
  • Parkinson’s disease
  • mitophagy
  • PINK1
  • Parkin

Fingerprint

Dive into the research topics of 'Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders'. Together they form a unique fingerprint.

Cite this