Role of FGF signalling in neural crest cell migration during early chick embryo development

Xiao-Tan Zhang, Guang Wang, Yan Li, Manli Chuai, Kenneth Ka Ho Lee, Xuesong Yang (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)
    362 Downloads (Pure)


    SummaryFibroblast growth factor (FGF) signalling acts as one of modulators that control neural crest cell (NCC) migration, but how this is achieved is still unclear. In this study, we investigated the effects of FGF signalling on NCC migration by blocking this process. Constructs that were capable of inducing Sprouty2 (Spry2) or dominant-negative FGFR1 (Dn-FGFR1) expression were transfected into the cells making up the neural tubes. Our results revealed that blocking FGF signalling at stage HH10 (neurulation stage) could enhance NCC migration at both the cranial and trunk levels in the developing embryos. It was established that FGF-mediated NCC migration was not due to altering the expression of N-cadherin in the neural tube. Instead, we determined that cyclin D1 was overexpressed in the cranial and trunk levels when Sprouty2 was upregulated in the dorsal neural tube. These results imply that the cell cycle was a target of FGF signalling through which it regulates NCC migration at the neurulation stage.

    Original languageEnglish
    Pages (from-to)457-464
    Number of pages8
    Issue number6
    Early online date6 Dec 2018
    Publication statusPublished - 6 Dec 2018


    • neural crest cells
    • FGF signaling
    • Sprouty2
    • EMT
    • cell cycle


    Dive into the research topics of 'Role of FGF signalling in neural crest cell migration during early chick embryo development'. Together they form a unique fingerprint.

    Cite this