Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

C. J. Weir (Lead / Corresponding author), S. J. Mitchell, J. J. Lambert

Research output: Contribution to journalArticle

12 Citations (Scopus)
101 Downloads (Pure)

Abstract

Since the introduction of general anaesthetics into clinical practice, researchers have been mystified as to how these chemically disparate drugs act to produce their dramatic effects on central nervous system function and behaviour. Scientific advances, particularly during the last 25 years, have now begun to reveal the molecular mechanisms underpinning their behavioural effects. For certain i.v. general anaesthetics, such as etomidate and propofol, a persuasive case can now be made that the GABAA receptor, a major inhibitory receptor in the mammalian central nervous system, is an important target. Advances in molecular pharmacology and in genetic manipulation of rodent genes reveal that different subtypes of the GABAA receptor are responsible for mediating particular aspects of the anaesthetic behavioural repertoire. Such studies provide a better understanding of the neuronal circuitry involved in the various anaesthetic-induced behaviours and, in the future, may result in the development of novel therapeutics with a reduced propensity for side-effects.

Original languageEnglish
Pages (from-to)i167-i175
Number of pages9
JournalBritish Journal of Anaesthesia
Volume119
Issue numberSuppl. 1
Early online date13 Dec 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Anaesthetics i.v.
  • Etomidate
  • Propofol
  • Receptors
  • GABAA receptors
  • Intravenous general anaesthetics

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