Role of hypoxia in the control of the cell cycle

Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya, Sonia Rocha (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    18 Citations (Scopus)
    67 Downloads (Pure)


    The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

    Original languageEnglish
    Article number4874
    Number of pages15
    JournalInternational Journal of Molecular Sciences
    Issue number9
    Publication statusPublished - 5 May 2021


    • 2-OGDs
    • Cell cycle
    • HIF
    • Hypoxia
    • Mitosis
    • PHDs
    • hypoxia
    • cell cycle
    • mitosis

    ASJC Scopus subject areas

    • Molecular Biology
    • Spectroscopy
    • Catalysis
    • Inorganic Chemistry
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry


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