Role of hypoxia in the control of the cell cycle

Jimena Druker; James W. Wilson; Fraser Child; Dilem Shakir; Temitope Fasanya; Sonia Rocha

doi:10.3390/ijms22094874

Role of hypoxia in the control of the cell cycle

Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya, Sonia Rocha (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

128 Downloads (Pure)

Abstract

The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

Original language	English
Article number	4874
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	9
DOIs	https://doi.org/10.3390/ijms22094874
Publication status	Published - 5 May 2021

Keywords

2-OGDs
Cell cycle
HIF
Hypoxia
Mitosis
PHDs
hypoxia
cell cycle
mitosis

ASJC Scopus subject areas

Molecular Biology
Spectroscopy
Catalysis
Inorganic Chemistry
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.3390/ijms22094874Licence: CC BY

Final Published VersionFinal published version, 2.48 MBLicence: CC BY

Cite this

@article{1d95ef2ae7cd4a67944ca452c27d0826,

title = "Role of hypoxia in the control of the cell cycle",

abstract = "The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.",

keywords = "2-OGDs, Cell cycle, HIF, Hypoxia, Mitosis, PHDs, hypoxia, cell cycle, mitosis",

author = "Jimena Druker and Wilson, {James W.} and Fraser Child and Dilem Shakir and Temitope Fasanya and Sonia Rocha",

note = "Funding Information: Funding: This research was funded by Wellcome Trust, grant number 206293/Z/17/Z; a TetFUND (Nigeria) scholarship to T.F.; and the University of Liverpool. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "5",

doi = "10.3390/ijms22094874",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "MDPI",

number = "9",

}

TY - JOUR

T1 - Role of hypoxia in the control of the cell cycle

AU - Druker, Jimena

AU - Wilson, James W.

AU - Child, Fraser

AU - Shakir, Dilem

AU - Fasanya, Temitope

AU - Rocha, Sonia

N1 - Funding Information: Funding: This research was funded by Wellcome Trust, grant number 206293/Z/17/Z; a TetFUND (Nigeria) scholarship to T.F.; and the University of Liverpool. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/5/5

Y1 - 2021/5/5

N2 - The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

AB - The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

KW - 2-OGDs

KW - Cell cycle

KW - HIF

KW - Hypoxia

KW - Mitosis

KW - PHDs

KW - hypoxia

KW - cell cycle

KW - mitosis

UR - http://www.scopus.com/inward/record.url?scp=85105223443&partnerID=8YFLogxK

U2 - 10.3390/ijms22094874

DO - 10.3390/ijms22094874

M3 - Review article

C2 - 34062959

AN - SCOPUS:85105223443

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 4874

ER -

Role of hypoxia in the control of the cell cycle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)

Cite this

Role of hypoxia in the control of the cell cycle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)

Cite this