Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

Yung-Chi Chang, Joshua Olson, Aaron Louie, Paul R. Crocker, Ajit Varki (Lead / Corresponding author), Victor Nizet (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)
    159 Downloads (Pure)


    Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of inhibitory sialic acid-binding immunoglobulin-like lectins (Siglecs) on host leukocytes. Expressed at high levels on splenic and lymph node macrophages, sialoadhesin (Sn) is a unique Siglec with an elongated structure that lacks intracellular signaling motifs. Sialoadhesin allows macrophage to engage certain sialylated pathogens and stimulate inflammatory responses, but the in vivo significance of sialoadhesin in infection has not been shown. We demonstrate that macrophages phagocytose the sialylated pathogen group B Streptococcus (GBS) and increase bactericidal activity via sialoadhesin-sialic-acid-mediated recognition. Sialoadhesin expression on marginal zone metallophillic macrophages in the spleen trapped circulating GBS and restricted the spread of the GBS to distant organs, reducing mortality. Specific IgM antibody responses to GBS challenge were also impaired in sialoadhesin-deficient mice. Thus, sialoadhesin represents a key bridge to orchestrate innate and adaptive immune defenses against invasive sialylated bacterial pathogens. Key message Sialoadhesin is critical for macrophages to phagocytose and clear GBS. Increased GBS organ dissemination in the sialoadhesin-deficient mice. Reduced anti-GBS IgM production in the sialoadhesin-deficient mice.

    Original languageEnglish
    Pages (from-to)951-959
    Number of pages9
    JournalJournal of Molecular Medicine
    Issue number9
    Early online date3 May 2014
    Publication statusPublished - Sept 2014


    Dive into the research topics of 'Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus'. Together they form a unique fingerprint.

    Cite this